A case-control study of occupation/industry and renal cell carcinoma risk
A case-control study of occupation/industry and renal cell carcinoma risk
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DOI：
10.1186/1471-2407-12-344
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发表时间：
2012-08-08
期刊：
影响因子：
3.8
通讯作者：
Purdue, Mark P.
中科院分区：
文献类型：
--
作者：
Karami, Sara;Colt, Joanne S.;Purdue, Mark P.
背景：职业在肾细胞癌（RCC）病因学中的作用尚不清楚。在这里，我们调查了就业在特定的职业和行业和RCC之间的关联，其最常见的组织学亚型，透明细胞RCC（ccRCC）。方法：在2002年和2007年之间，以人群为基础的病例对照研究，白人和非洲裔美国人（1,217例，1,235对照）进行了底特律和芝加哥大都市地区调查RCC的危险因素。作为本研究的一部分，通过面对面访谈确定了职业史。我们使用调整后的非条件logistic回归模型计算了职业和行业与RCC风险相关的比值比（OR）和95%置信区间（CI）。在农业作物生产行业工作五年或五年以上与RCC相关（OR = 3.3 [95% CI = 1.0-11.5]），尤其是ccRCC（OR = 6.3 [95% CI = 1.7-23.3]，就业时间趋势P = 0.0050）。同样，在非管理性农业和相关职业中工作5年或更长时间的RCC风险升高（ORRCC = 2.1 [95%CI = 1.0-4.5]; ORccRCC = 3.1 [95%CI = 1.4-6.8]）。从事干洗行业也与风险升高相关（ORRCC = 2.0 [95% CI = 0.9-4.4]，趋势P = 0.093; ORccRCC = 3.0 [95% CI = 1.2-7.4]，趋势P = 0.031）。在警察/公共安全工作者、医疗保健工作者和技术人员以及电子、汽车修理和清洁/清洁服务行业的就业中观察到了暗示性升高的协会;在许多白领工作中，包括计算机科学和行政职业以及商业、立法和教育行业的就业中，建议了保护性协会。我们的研究结果为农业和干洗行业的RCC风险升高提供了支持，并表明这些协会可能对ccRCC亚型更强。需要更多的研究来证实这些发现。
Background: The role of occupation in the etiology of renal cell carcinoma (RCC) is unclear. Here, we investigated associations between employment in specific occupations and industries and RCC, and its most common histologic subtype, clear cell RCC (ccRCC).Methods: Between 2002 and 2007, a population-based case-control study of Caucasians and African Americans (1,217 cases; 1,235 controls) was conducted within the Detroit and Chicago metropolitan areas to investigate risk factors for RCC. As part of this study, occupational histories were ascertained through in-person interviews. We computed odds ratios (ORs) and 95% confidence intervals (CIs) relating occupation and industry to RCC risk using adjusted unconditional logistic regression models.Results: Employment in the agricultural crop production industry for five years or more was associated with RCC (OR = 3.3 [95% CI = 1.0-11.5]) and ccRCC in particular (OR = 6.3 [95% CI = 1.7-23.3], P for trend with duration of employment = 0.0050). Similarly, RCC risk was elevated for employment of five years or longer in non-managerial agricultural and related occupations (ORRCC = 2.1 [95% CI = 1.0-4.5]; ORccRCC = 3.1 [95% CI = 1.4-6.8]). Employment in the dry-cleaning industry was also associated with elevated risk (ORRCC = 2.0 [95% CI = 0.9-4.4], P for trend = 0.093; ORccRCC = 3.0 [95% CI = 1.2-7.4], P for trend = 0.031). Suggestive elevated associations were observed for police/public safety workers, health care workers and technicians, and employment in the electronics, auto repair, and cleaning/janitorial services industries; protective associations were suggested for many white-collar jobs including computer science and administrative occupations as well employment in the business, legislative, and education industries.Conclusions: Our findings provide support for an elevated risk of RCC in the agricultural and dry-cleaning industries and suggest that these associations may be stronger for the ccRCC subtype. Additional studies are needed to confirm these findings.