INFLUENCE OF HORMONES ON LYMPHOID TISSUE STRUCTURE AND FUNCTION. THE ROLE OF THE PITUITARY ADRENOTROPHIC HORMONE IN THE REGULATION OF THE LYMPHOCYTES AND OTHER CELLULAR ELEMENTS OF THE BLOOD1
INFLUENCE OF HORMONES ON LYMPHOID TISSUE STRUCTURE AND FUNCTION. THE ROLE OF THE PITUITARY ADRENOTROPHIC HORMONE IN THE REGULATION OF THE LYMPHOCYTES AND OTHER CELLULAR ELEMENTS OF THE BLOOD1
复制标题
激素对淋巴组织结构和功能的影响。
DOI：
10.1210/endo-35-1-1
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发表时间：
1944
期刊：
影响因子：
4.8
通讯作者：
A. White
中科院分区：
文献类型：
--
作者：
T. Dougherty;A. White
健康和疾病状态下血细胞数量的巨大差异并没有促使研究人员假设控制这些元素的共同调节机制。然而，考虑到造血组织的增殖能力，正常受试者中血细胞波动的数值界限的存在是值得注意的。似乎存在着某种机制，可以抑制这些组织的细胞产物积累的程度。几位研究者根据临床观察，提出了各种内分泌腺对造血组织的影响。Drinker和Yoffey（1941）对这一问题进行了评论。本文的目的是提供实验证据，垂体促肾上腺激素是调节血液淋巴细胞数量的一个因素。这种激素也可能与某些骨髓元素的调节有关。
THE WIDE VARIATIONS in the numbers of the blood cells in health and disease have not encouraged investigators to postulate a common regulatory mechanism controlling these elements. Yet the existence of numerical limits between which the blood cells fluctuate in the normal subject is remarkable in view of the proliferative capacity of the blood-forming tissues. It seems likely that mechanisms exist which restrain the degree to which the cellular products of these tissues accumulate. An influence of various endocrine glands on hematopoietic tissues has been suggested by several investigators on the basis of clinical observations. This subject has been reviewed by Drinker and Yoffey (1941). It is the object of this paper to present experimental evidence that the pituitary adrenotrophic hormone is a factor in the regulation of the number of blood lymphocytes. This hormone may also be concerned with the regulation of certain bone marrow elements.