Origin, regulation and physiological function of intestinal oeosinophils
Origin, regulation and physiological function of intestinal oeosinophils
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DOI：
10.1016/j.bpg.2007.10.023
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发表时间：
2008-01-01
影响因子：
3.2
通讯作者：
Rothenberg, Marc E.
中科院分区：
文献类型：
--
作者：
Fulkerson, Patricia C.;Rothenberg, Marc E.
嗜酸性粒细胞是多效多功能白细胞，通常与炎症反应的引发和传播相关，特别是蠕虫感染和过敏性疾病。然而，越来越多的证据支持嗜酸性粒细胞在稳态功能和器官发育以及通过与其他效应细胞相互作用调节局部免疫反应中发挥更广泛的作用。在这篇综述中，总结了健康肠道中嗜酸性粒细胞的生物学特性。特别是，描述了涉及嗜酸性粒细胞发育和运输的分子步骤，特别关注转录因子 GATA-1、嗜酸性粒细胞选择性细胞因子 IL-5 和趋化因子嗜酸粒细胞趋化因子亚家族的重要作用。此外，还回顾了抑制性和死亡受体对嗜酸性粒细胞存活的调节以及嗜酸性粒细胞在健康和疾病中的扩大作用。
Oeosinophils are pleiotropic multi-functional leukocytes that are typically associated with the initiation and propagation of inflammatory responses, particularly helminth infection and allergic disease. However, expanding evidence supports a broader role for oeosinophils in homoeostatic function and organ development and modulation of local immune responses via interaction with other effector cells. In this review, the biology of oeosinophils in the healthy gut is summarised. In particular, the molecular steps involved in oeosinophil development and trafficking are described, with special attention to the important role of the transcription factor GATA-1, the oeosinophil-selective cytokine IL-5 and the eotaxin subfamily of chemokines. In addition, the regulation of oeosinophil survival by inhibitory and death receptors and the expanding role for oeosinophils in health and disease are reviewed.