C–O-Selective Cross-Coupling of Chlorinated Phenol Derivatives
C–O-Selective Cross-Coupling of Chlorinated Phenol Derivatives
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DOI：
10.1055/a-1503-6330
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发表时间：
2021-05
期刊：
影响因子：
2
通讯作者：
Sharon R. Neufeldt;John E. A. Russell
中科院分区：
文献类型：
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作者：
Sharon R. Neufeldt;John E. A. Russell
苯酚衍生物的化学选择性交叉偶联对于生成保留卤化物的产物是有价值的。在这里，我们讨论了氯芳基苯酚衍生物选择性交叉偶联的最新进展，特别关注氯芳基苯甲酸酯的反应。详细讨论了c - o选择性镍催化氯芳基苯甲酸酯Suzuki-Miyaura偶联的第一个例子。1 .介绍2 .镍氧化加成的密度泛函理论研究3 .氧化加成的化学计量学研究4 . tosyl - selective Suzuki偶联的发展5 .结论与展望
Abstract Chemoselective cross-coupling of phenol derivatives is valuable for generating products that retain halides. Here we discuss recent developments in selective cross-couplings of chloroaryl phenol derivatives, with a particular focus on reactions of chloroaryl tosylates. The first example of a C–O-selective Ni-catalyzed Suzuki–Miyaura coupling of chloroaryl tosylates is discussed in detail. 1 Introduction 2 Density Functional Theory Studies on Oxidative Addition at Nickel(0) 3 Stoichiometric Oxidative Addition Studies 4 Development of a Tosylate-Selective Suzuki Coupling 5 Conclusion and Outlook