Connectable DNA Logic Gates: OR and XOR Logics
Connectable DNA Logic Gates: OR and XOR Logics
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DOI：
10.1002/asia.201100664
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发表时间：
2012-03-05
影响因子：
4.1
通讯作者：
Kolpashchikov, Dmitry M.
中科院分区：
文献类型：
--
作者：
Gerasimova, Yulia V.;Kolpashchikov, Dmitry M.
现代计算机处理器是基于在复杂电路中相互连接的半导体逻辑门。这项研究有助于开发一类新的由DNA组成的可连接逻辑门，其中作为输入/输出信号的寡核苷酸片段的转移发生在DNA序列的杂交上。当信号高时，负责逻辑功能的DNA链形成含有固定DNA四结结构的联系物，当信号低时，分离成单独的链。设计了一组基本的逻辑门（非、与、或）。两个非门、两个与门和一个或门连接在一个网络中，对应于一个异或逻辑功能。这里提出的逻辑门的设计可能有助于第一台生物相容性分子计算机的发展。
Modern computer processors are based on semiconductor logic gates connected to each other in complex circuits. This study contributes to the development of a new class of connectable logic gates made of DNA in which the transfer of oligonucleotide fragments as input/output signals occurs upon hybridization of DNA sequences. The DNA strands responsible for a logic function form associates containing immobile DNA four-way junction structures when the signal is high and dissociate into separate strands when the signal is low. A basic set of logic gates (NOT, AND, and OR) was designed. Two NOT gates, two AND gates, and an OR gate were connected in a network that corresponds to an XOR logic function. The design of the logic gates presented here may contribute to the development of the first biocompatible molecular computer.