RESOLVED AND UNRESOLVED ISSUES IN THE PREVENTION AND TREATMENT OF CORONARY-ARTERY DISEASE - A WORKSHOP CONSENSUS STATEMENT
RESOLVED AND UNRESOLVED ISSUES IN THE PREVENTION AND TREATMENT OF CORONARY-ARTERY DISEASE - A WORKSHOP CONSENSUS STATEMENT
复制标题
DOI：
10.1016/0002-8703(91)90694-d
复制
发表时间：
1991-04-01
影响因子：
4.8
通讯作者：
BRAUNWALD, E
中科院分区：
文献类型：
--
作者：
DZAU, V;BRAUNWALD, E
在过去的二十年中，心血管研究的进展使人们对导致终末期冠状动脉疾病的事件链有了更好的理解。这些发展已经被治疗上的进步所证实，现在有可能在晚期心脏病发展的几乎每个阶段进行干预，从有发生冠状动脉粥样硬化风险的无症状患者到终末期心力衰竭患者。通过中断这一事件链，也许在多个部位，有可能预防或减缓症状性心脏病的发展，并有望延长生命。存在许多机会来获得关于潜在病理生理学的进一步信息，旨在预防和/或治疗心肌缺血和心力衰竭发展的干预措施的基本作用机制，以及有利地影响各种形式心脏病的自然史。
Advances in cardiovascular research during the past two decades have resulted in an improved understanding of the chain of events that lead to end-stage coronary artery disease. These developments have been paralleled by therapeutic advances that now make it possible to intervene at virtually every stage in the development of advanced cardiac disease, from asymptomatic persons at risk of developing coronary atherosclerosis to patients with end-stage heart failure. By interrupting this chain of events, perhaps at multiple sites, it may be possible to prevent or slow the development of symptomatic heart disease and hopefully prolong life. Many opportunities exist for obtaining further information regarding the underlying pathophysiology, the fundamental mechanisms of action of interventions designed to prevent and/or treat the development of myocardial ischemia and cardiac failure and for effecting favorably the natural history of various forms of heart disease.