Expression of heparin-binding EGF-like growth factor in rat liver injured by carbon tetrachloride or D-Galactosamine
Expression of heparin-binding EGF-like growth factor in rat liver injured by carbon tetrachloride or D-Galactosamine
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DOI：
10.1006/bbrc.1996.0397
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发表时间：
1996-03-18
影响因子：
3.1
通讯作者：
Matsuzawa, Y
中科院分区：
文献类型：
--
作者：
Kiso, S;Kawata, S;Matsuzawa, Y
We reported recently that hepatin-binding EGF-like growth factor (HB-EGF), a member of the EGF family, is a new hepatotrophic factor for the regeneration of rat liver after partial hepatectomy. The current study examined changes in the amount of HB-EGF mRNA in Liver injured by hepatotoxins. The level of HB-EGF mRNA was very low in normal rat liver, but increased markedly in the Liver of rats injured by CCl4, showing two peaks, the first at 6 h and the second at 36 h. Western blot analysis showed that HB-EGF protein in the liver of CCl4-treated rats (at 6 h) was increased about 3.4-fold above normal The level of HB-EGF mRNA also increased markedly in the Liver of rats treated with D-galactosamine, showing a major peak at 18 h, and a smaller one at 6 h. These results indicate that HB-EGF may play a role in the regeneration of the liver following hepatotoxic injury. (C) 1996 Academic Press, Inc.
