Development of methionine-enkephalin in microdissected areas of the rabbit brain.
Development of methionine-enkephalin in microdissected areas of the rabbit brain.
复制标题
兔脑显微解剖区域蛋氨酸脑啡肽的发育。
DOI：
10.1016/0006-8993(85)90417-2
复制
发表时间：
1985
期刊：
影响因子：
2.9
通讯作者：
Lawson,EE
中科院分区：
文献类型：
--
作者：
Gingras-Leatherman,JL;McNamara,MC;Hong,JS;Lawson,EE
Microdissected areas of the rabbit brain were isolated at prenatal day E-29, postnatal days P-3, 7, 14, 21, 2 months and adults. Methionine-enkephalin (ME) was assayed by RIA and ME concentration [ME] was expressed relative to the protein content of the extracted brain tissues. In brain nuclei with important roles in respiratory control [ME] was higher in prenatal and early postnatal life than in adults. In contrast, the prenatal and early postnatal [ME] levels in other nuclei were lower than or equal to adult values. These data suggest an important and changing role for ME in respiratory control throughout development. Early high [ME] levels within brainstem respiratory control nuclei may contribute to the newborn's increased susceptibility to respiratory depression.
