Disrupted resting-state functional connectivity of the hippocampus in medication-naive patients with major depressive disorder
Disrupted resting-state functional connectivity of the hippocampus in medication-naive patients with major depressive disorder
复制标题
DOI：
10.1016/j.jad.2012.03.002
复制
发表时间：
2012-12-10
影响因子：
6.6
通讯作者：
Zhang, Kerang
中科院分区：
文献类型：
--
作者：
Cao, Xiaohua;Liu, Zhifen;Zhang, Kerang
背景：据报道，重度抑郁症（MDD）患者的海马体在结构和功能上会发生改变。但该区域与其他区域之间的功能关系仍不明确。
方法：对静息态功能磁共振成像数据进行基于感兴趣区的相关性分析，以检测未用药的MDD患者和健康成年人之间海马体功能连接（FC）的差异。对临床变量与显示组间差异的区域中FC的强度进行相关性分析。
结果：在双侧边缘系统、皮质下区域、颞叶、内侧和下额叶皮质中观察到与海马感兴趣区呈正性FC，而在双侧额叶皮质、顶叶和枕叶皮质以及小脑中观察到负性FC。组间比较显示，MDD患者海马体的功能连接受损，左侧海马感兴趣区与双侧额中回之间缺乏负性FC，右侧海马感兴趣区与右侧顶下小叶皮质和小脑之间的负性FC降低。疾病持续时间与额叶和顶叶皮质中FC的强度呈负相关。
局限性：在种子区域的定义和FC的计算方面，考虑海马体积个体差异的优化方法是有价值的。需要进一步招募具有阈下抑郁症状的受试者进行研究。
结论：海马体与皮质区域之间的异常功能关系可能是MDD病理生理学的基础。（C）2012爱思唯尔有限公司。保留所有权利。
Background: The hippocampus has been reported to exhibit structural and functional alterations in patients with major depressive disorder (MDD). But functional relationships between this area and other regions remain unclear.Methods: Region of interest-based correlation analyses were performed in the resting-state functional magnetic resonance imaging data to examine differences in functional connectivity (FC) of the hippocampus between medication-naive patients with MDD and healthy adults. Correlation analyses were done between clinical variables and the strength of FC in regions showing group differences.Results: Positive FC with the hippocampal-ROIs was seen in bilateral limbic system, subcortical areas, temporal lobe, medial and inferior prefrontal cortex while negative FC was observed in bilateral prefrontal cortex, parietal and occipital cortex and the cerebellum. Group comparison showed impaired functional connections of the hippocampus in MDD, with a lack of negative FC in left hippocampal-ROI to bilateral middle frontal gyrus, as well as decreased negative FC in right hippocampal-ROI to right inferior parietal cortex and the cerebellum. Negative correlations were seen between illness duration and the strength of FC in the prefrontal and parietal cortex.Limitations: An optimized method taking individual variability of hippocampal volume into account is merited for the definition of seed regions and computation of FC. Further studies recruiting subjects with subthreshold depressive symptoms are needed.Conclusions: Abnormal functional relationships between the hippocampus and cortical areas may underlie the pathophysiology of MDD. (C) 2012 Elsevier B.V. All rights reserved.