Altered cardiovascular variability in obstructive sleep apnea
Altered cardiovascular variability in obstructive sleep apnea
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DOI：
10.1161/01.cir.98.11.1071
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发表时间：
1998-09-15
期刊：
影响因子：
37.8
通讯作者：
Somers, VK
中科院分区：
文献类型：
--
作者：
Narkiewicz, K;Montano, N;Somers, VK
背景改变的心血管变异性是心血管事件的预后指标。患有阻塞性睡眠呼吸暂停（OSA）的患者患心血管疾病的风险增加。我们检验了 OSA 伴随着心血管变异性改变的假设，即使没有明显的心血管疾病。方法和结果——对 15 名中重度 OSA 患者、18 名轻度 OSA 患者和 16 名健康对照受试者（其中通过整夜多导睡眠图排除了睡眠呼吸障碍）在不受干扰的仰卧休息期间获得了肌肉交感神经活动、RR 间期和血压变异性的频谱分析。 OSA 患者是新诊断的，从未接受过 OSA 治疗，并且没有任何其他已知疾病。与对照受试者（947+/-42 ms；24+/-3 爆发/分钟；P=0.008 和 P
Background-Altered cardiovascular variability is a prognostic indicator for cardiovascular events. Patients with obstructive sleep apnea (OSA) are at an increased risk for cardiovascular disease. We tested the hypothesis that OSA is accompanied by alterations in cardiovascular variability, even in the absence of overt cardiovascular disease.Methods and Results-Spectral analysis of variability of muscle sympathetic nerve activity, RR interval, and blood pressure were obtained during undisturbed supine rest in 15 patients with moderate-to-severe OSA, 18 patients with mild OSA, and 16 healthy control subjects in whom sleep disordered breathing was excluded by complete overnight polysomnography. Patients with OSA were newly diagnosed, never treated for OSA, and free of any other known diseases. Patients with moderate-to-severe OSA had shorter RR intervals (793+/-27 ms) and increased sympathetic burst frequency (49+/-4 bursts/min) compared with control subjects (947+/-42 ms; 24+/-3 bursts/min; P=0.008 and P