Effect of genetic variations in platelet glycoproteins Ibα and VI on the risk for coronary heart disease events in postmenopausal women taking hormone therapy
Effect of genetic variations in platelet glycoproteins Ibα and VI on the risk for coronary heart disease events in postmenopausal women taking hormone therapy
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DOI：
10.1182/blood-2006-03-013151
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发表时间：
2007-03-01
期刊：
影响因子：
20.3
通讯作者：
Herrington, David M.
中科院分区：
文献类型：
--
作者：
Bray, Paul F.;Howard, Timothy D.;Herrington, David M.
数以百万计的妇女仍然使用绝经后激素治疗（HT）。我们对2090名参与心脏和雌激素/孕酮替代研究的女性进行了GP 18 A和GP 6功能多态性的基因分型，并评估了5.8年随访期间的冠心病（CHID）事件发生率。在接受安慰剂治疗的患者中，GP 1BA-5C等位基因携带者的CHD死亡/心肌梗死（MI）/不稳定型心绞痛（UA）事件发生率增加（调整后P =.006）。HT使GP 1BA-5 TT基因型患者的CHD事件风险比（HR）增加16%，使TC+CC基因型患者的HR降低46%（adj交互作用P <0.001）。HT使GP 6 13254 TT基因型患者的HR降低17%，但使TC+CC基因型患者的HR增加35%（adj相互作用P <0.001）。此外，HT使GP 1BA-5 TT + GP 613254 TC +CC基因型患者的CHD事件HR增加57%，使GP 1BA-5 TC +CC + GP 613254 TT基因型患者的HR降低55%（adj交互作用P
Millions of women still use postmenopausal hormone therapy (HT). We genotyped 2090 women in Heart and Estrogen/ progestin Replacement Study for functional polymorphisms in GP18A and GP6 and assessed the coronary heart disease (CHID) event rate over 5.8 years of followup. In patients receiving placebo, there was an increased CHD death/myocardial infarction (MI)/unstable angina (UA) event rate in carriers of the GP1BA -5C allele (adjusted [adj] P =.006). HT increased the hazard ratio (HR) of CHD events in patients with the GP1BA -5TT genotype by 16% and reduced the HR in patients with the TC+CC genotypes by 46% (adj interaction P < .001). HT reduced the HR in patients with the GP6 13254TT genotype by 17% but increased the HR in patients with the TC+CC genotypes by 35% (adj interaction P < .001). Furthermore, HT increased the HR of CHD events in patients with the GP1BA -5TT plus GP613254TC+CC genotypes by 57% and reduced the HR in patients with the GP1BA -5TC+CC plus GP613254TT genotypes by 55% (adj interaction P