RELATIONSHIP BETWEEN HYPERLIPIDEMIA, LIPID MEDIATORS, AND PROGRESSIVE GLOMERULOSCLEROSIS IN THE NEPHROTIC SYNDROME
RELATIONSHIP BETWEEN HYPERLIPIDEMIA, LIPID MEDIATORS, AND PROGRESSIVE GLOMERULOSCLEROSIS IN THE NEPHROTIC SYNDROME
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DOI：
10.1159/000168651
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发表时间：
1993-09-01
影响因子：
4.2
通讯作者：
DIAMOND, JR
中科院分区：
文献类型：
--
作者：
KEESFOLTS, D;DIAMOND, JR
肾病综合征的定义是蛋白尿、低蛋白血症、水肿和高胆固醇血症。实验和临床文献的证据表明，高脂质水平不仅是疾病的标志，而且还促进肾小球硬化的过程。脂质介质，包括类二十烷酸、血小板激活因子和趋化因子，可以通过影响白细胞浸润、系膜增殖、细胞外基质蛋白产生、血管反应性和凝血来发挥作用。浸润巨噬细胞可能在这些过程中发挥核心作用。旨在纠正血脂异常的治疗措施可能会阻止或减缓肾病综合征向终末期肾病的进展。
Nephrotic syndrome is defined by proteinuria, hypoalbuminemia, edema and hypercholesterolemia. Evidence from both the experimental and clinical literature suggests that high lipid levels are not only a marker of disease, but also contribute to the process of glomerulosclerosis. Lipid mediators, including eicosanoids, platelet-activating factor, and chemotactic factors, can contribute by effecting leukocyte infiltration, mesangial proliferation, extracellular matrix protein production, vasoreactivity, and coagulation. Infiltrating macrophages may play a central role in these processes. Therapeutic maneuvers aimed at the correction of lipid abnormalities may halt or slow the progression of nephrotic syndrome to end-stage renal disease.