Gene expression regulation and domain function of hematopoietic GATA factors.
Gene expression regulation and domain function of hematopoietic GATA factors.
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DOI：
10.1016/j.semcdb.2004.11.001
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发表时间：
2005-02
影响因子：
7.3
通讯作者：
R. Shimizu;Masayuki Yamamoto
中科院分区：
文献类型：
--
作者：
R. Shimizu;Masayuki Yamamoto
造血过程中的分层基因调控网络非常复杂，使得阐明造血细胞的规范和分化过程成为一项具有挑战性的任务。最近的发现揭示了 GATA 因子是造血遗传控制的核心。特别是，造血发育在分子水平上受到GATA-1和GATA-2广泛而精确的调控。我们希望强调 GATA-1 和 GATA-2 之间与细胞发育有关的调控关系。先进的实验遗传学方法提供的证据表明，该网络的异常可能导致多种血液疾病。最引人注目的新发现是 GATA-1 功能障碍导致白血病的新发病机制。
The hierarchical gene regulatory network in hematopoiesis is highly complex, making elucidation of the processes of specification and differentiation of hematopoietic cells a challenging task. Recent discoveries have divulged the GATA factors as central to the genetic control of hematopoiesis. In particular, hematopoietic development is subject to extensive and precise regulation of GATA-1 and GATA-2 at the molecular level. We wish to emphasize the regulatory relationships between GATA-1 and GATA-2 implicated in cell development. An advanced experimental genetic approach has provided evidence that abnormalities in this network may result in a variety of blood disorders. The most striking new finding is the novel pathogenesis arising from GATA-1 dysfunction that leads to leukemia.