Biomarkers for Infants at Risk for Necrotizing Enterocolitis: Clues to Prevention?
Biomarkers for Infants at Risk for Necrotizing Enterocolitis: Clues to Prevention?
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DOI：
10.1203/pdr.0b013e31819dba7d
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发表时间：
2009-05-01
影响因子：
3.6
通讯作者：
Neu, Josef
中科院分区：
文献类型：
--
作者：
Young, Christopher;Sharma, Renu;Neu, Josef
坏死性小肠结肠炎（NEC）是影响早产儿的最常见的严重胃肠道急症。这种疾病通常具有快速发作，几乎没有（如果有的话）可用于可靠预测其发生的前驱体征。该病发病迅速，发展至死亡，而且婴儿存活后发病率很高，因此需要有早期诊断工具，以确定哪些婴儿最有可能患上这种疾病，并可针对哪些婴儿采取早期预防措施。虽然研究表明了几种技术的有效性，如呼吸氢，血液，尿液或粪便中的炎症介质，以及遗传标记，但这些都有限制其使用的缺点。新开发的“组学”方法的应用可能为该疾病的早期诊断和靶向预防提供生物标志物。（儿科研究65：91 R-97 R，2009年）
Necrotizing enterocolitis (NEC) is the most common severe gastrointestinal emergency that affects premature newborns. This disease often has a rapid onset with few, if any, antecedent signs that can be used to reliably predict its occurrence. Its rapid onset and progression to death, as well as its severe morbidity when the infant survives, begs for early diagnostic tools that may be used in determining those infants who would be at greatest risk for development of the disease and for whom early preventative measures could be targeted. Although studies have suggested efficacy of several techniques such as breath hydrogen, inflammatory mediators in blood, urine or stool, and genetic markers, these all have drawbacks limiting their use. The application of newly developed "omic" approaches may provide biomarkers for early diagnosis and targeted prevention of this disease. (Pediatir Res 65: 91R-97R, 2009)