EFFECT OF THE EPIDERMAL GROWTH-FACTOR (EGF) ON THE CORNEAL EPITHELIUM IN HUMANS
EFFECT OF THE EPIDERMAL GROWTH-FACTOR (EGF) ON THE CORNEAL EPITHELIUM IN HUMANS
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DOI：
10.1007/bf00414564
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发表时间：
1979-01-01
期刊：
影响因子：
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通讯作者：
SANTONI, G
中科院分区：
文献类型：
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作者：
DANIELE, S;FRATI, L;SANTONI, G
表皮生长因子（EGF）是一种存在于哺乳动物器官中的多肽激素。在体内，它通过刺激角膜上皮的显著细胞增殖来缩短角膜上皮再生的时间过程。在培养的人角膜上皮和表皮中证实了体内的进一步直接作用。在几种角膜上皮非营养不良性疾病中的试验证实了以前在兔子中观察到的EGF加速上皮愈合的过程。角膜基质的完整性不利于EGF的最大效果，在这个意义上，基质受损越深，EGF的作用越小。在疱疹性病变[单纯疱疹] EGF是有效的48小时内，只有当病毒感染的区域角膜上皮已被刮掉。表皮生长因子被认为是一种新的和有效的代理人，增加角膜上皮细胞在许多非营养不良性疾病的恢复过程。
Epidermal growth factor (EGF) is a polypeptide hormone present in mammalian organs. In vivo, it shortens the time course of the corneal reepitheliazation by stimulating a marked cell proliferation of the corneal epithelium. A further direct effect in vivo was confirmed on human corneal epithelium and epidermis in culture. Tests in several nondystrophic diseases of the corneal epithelium confirmed the observations previously made in the rabbit that EGF accelerates the process of epithelial healing. The integrity of the corneal stroma is prejudicial for the maximum effect of the EGF, in the sense that the deeper the stroma is damaged, the less EGF acts. In herpetic lesions [Herpes simplex] EGF is effective within 48 h only when the virus-affected area of the corneal epithelium has been scraped off. EGF is proposed as a new and efficacious agent for increasing the restorative process of the corneal epithelium in many nondystrophic diseases.