Genetic basis of human brain evolution.
Genetic basis of human brain evolution.
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DOI：
10.1016/j.tins.2008.08.010
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发表时间：
2008-12
影响因子：
15.9
通讯作者：
Lahn, Bruce T.
中科院分区：
文献类型：
--
作者：
Vallender, Eric J.;Mekel-Bobrov, Nitzan;Lahn, Bruce T.
Human evolution is characterized by a rapid increase in brain size and complexity. Decades of research have made important strides in identifying anatomical and physiological substrates underlying the unique features of the human brain. By contrast, it has become possible only very recently to examine the genetic basis of human brain evolution. Through comparative genomics, tantalizing insights regarding human brain evolution have emerged. The genetic changes that potentially underlie human brain evolution span a wide range from single nucleotide substitutions to large-scale structural alterations of the genome. Similarly, the functional consequences of these genetic changes vary greatly, including protein-sequence alterations, cis-regulatory changes and even the emergence of new genes and the extinction of existing ones. Here, we provide a general review of recent findings into the genetic basis of human brain evolution, highlight the most notable trends that have emerged and caution against overinterpretation of current data.
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作者：
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通讯作者：
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影响因子：
64.8
作者：
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作者：
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Woods, CG
DOI：
10.1073/pnas.0604066103
发表时间：
2006-07-05
影响因子：
11.1
作者：
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通讯作者：
Huttner, Wieland B.