Anthropometric indicators of body composition in young adults: relation to size at birth and serial measurements of body mass index in childhood in the New Delhi birth cohort
Anthropometric indicators of body composition in young adults: relation to size at birth and serial measurements of body mass index in childhood in the New Delhi birth cohort
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DOI：
10.1093/ajcn/82.2.456
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发表时间：
2005-08-01
影响因子：
7.1
通讯作者：
Bhargava, SK
中科院分区：
文献类型：
--
作者：
Sachdev, HS;Fall, CH;Bhargava, SK
背景：南亚人的身体表型是肌肉薄但脂肪多，肥胖相关疾病的发病率很高。成人身体成分可能在生命早期是可预测的。目的：检查成人身体成分的人体测量指数与出生体重和儿童时期体重指数 (BMI) 的关系。设计：印度德里 1526 名 26-32 岁男性和女性的人口队列，对他们从出生到 21 岁进行连续测量并进行随访。测量成人体重、身高、皮褶厚度以及腰围和臀围。得出 BMI 和肥胖指数（皮褶厚度总和）、中心肥胖指数（腰臀比）和瘦体重（根据皮褶厚度和高度调整 BMI 后的残差值）。 结果：平均出生体重为 2851 克。作为儿童，许多受试者的年龄体重不足（比国家健康统计中心平均值低 2 个标准差；2 岁时为 53%），但作为成年人，47% 的人超重，11% 的人肥胖，51% 的人中心性肥胖（根据世界卫生组织的标准）。出生体重与成人瘦体重（P < 0.001）呈正相关，并且仅在女性中与肥胖（P = 0.006）呈正相关，但与中心性肥胖无关。从出生到 21 岁的 BMI 与所有结果呈越来越强的正相关。婴儿期和幼儿期的 BMI 和 BMI 增加与成人去脂体重的相关性比与肥胖或中心性肥胖的相关性更强。较高的 BMI 以及儿童晚期和青春期的 BMI 增加与成人肥胖和中心性肥胖增加相关。结论：出生体重和婴儿期和儿童早期的 BMI 增加比成人肥胖更能预测成人瘦体重。儿童晚期和青春期体重指数的增加预示着成人肥胖的增加。
Background: South Asians have a muscle-thin but adipose body phenotype and high rates of obesity-related disease. Adult body composition may be predictable in early life.Objective: Anthropometric indexes of adult body composition were examined in relation to birth size and body mass index (BMI) during childhood.Design: A population-based cohort of 1526 men and women aged 26-32 y in Delhi, India, who were measured sequentially from birth until 21 y of age were followed up. Adult weight, height, skinfold thicknesses, and waist and hip circumferences were measured. BMI and indexes of adiposity (sum of skinfold thicknesses), central adiposity (waist-hip ratio), and lean mass (residual values after adjustment of BMI for skinfold thicknesses and height) were derived.Results: Mean birth weight was 2851 g. As children, many subjects were underweight-for-age (> 2 SDs below the National Center for Health Statistics mean; 53% at 2 y), but as adults, 47% were overweight, 11% were obese, and 51% were centrally obese (according to World Health Organization criteria). Birth weight was positively related to adult lean mass (P < 0.001) and, in women only, to adiposity (P = 0.006) but was unrelated to central adiposity. BMI from birth to age 21 y was increasingly strongly positively correlated with all outcomes. BMI and BMI gain in infancy and early childhood were correlated more strongly with adult lean mass than with adiposity or central adiposity. Higher BMI and greater BMI gain in late childhood and adolescence were associated with increased adult adiposity and central adiposity.Conclusions: Birth weight and BMI gain during infancy and early childhood predict adult lean mass more strongly than adult adiposity. Greater BMI gain in late childhood and adolescence predicts increased adult adiposity.