Attenuation of rat chronic small bowel allograft rejection by n‐3 polyunsaturated fatty acids is associated with reduced expression of graft IL‐15
Attenuation of rat chronic small bowel allograft rejection by n‐3 polyunsaturated fatty acids is associated with reduced expression of graft IL‐15
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n-3 多不饱和脂肪酸减轻大鼠慢性小肠同种异体移植排斥反应与移植物 IL-15 表达减少相关
DOI：
10.1111/petr.12120
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发表时间：
2013
影响因子：
1.3
通讯作者：
Jie‐shou Li
中科院分区：
文献类型：
--
作者：
Jian Wang;Yousheng Li;Jie‐shou Li
白细胞介素-15被发现在各种免疫过程中发挥关键作用，包括肾和心脏移植后的慢性排斥反应。n-3多不饱和脂肪酸（n-3 PUFA）已显示出对慢性同种异体移植排斥的有益作用。本研究的目的是寻找这种抑制小肠移植慢性排斥反应的可能机制。将动物分为三组：同种移植物（CsA +玉米油补充饲料）;同种异体移植物（CsA +玉米油补充饲料）;和同种异体移植物（CsA +鱼油补充饲料）。将F344大鼠的供体肠原位移植到刘易斯大鼠受体中。术后给予CsA 5 mg/kg/天，持续2周。记录移植后体重。在POD 90测量组织学变化和移植物IL-15表达。术后第90天发生慢性小肠移植排斥反应。n-3 PUFA显著降低了慢性排斥反应评分，并增加了术后体重增加率。这种减毒与移植物IL-15表达减少有关。n-3 PUFA有助于改善慢性小肠同种异体移植排斥反应期间的病理和临床结局，这种改善与移植物IL-15表达降低相关。
Interleukin‐15 was found to play key roles in various immunological processes including chronic rejection after renal and cardiac transplantation. n‐3 polyunsaturated fatty acids (n‐3 PUFA) have shown beneficial effects to chronic allograft rejection. The objective of this study is to search the possible mechanism of this inhibitory effect in chronic small bowel allograft rejection. Animals were divided into three groups: isograft (CsA + corn oil‐supplemented diet); allograft (CsA + corn oil‐supplemented diet); and allograft (CsA + fish oil‐supplemented diet). Donor intestines from F344 rats were transplanted orthotopically into Lewis rat recipients. CsA was administered at 5 mg/kg/day for 2 wk post‐operatively. Post‐transplant weight was recorded. Histopathological changes and graft IL‐15 expression were measured on POD 90. Chronic small bowel allograft rejection developed on POD 90. n‐3 PUFA significantly decreased the score of chronic rejection and increased the post‐operative weight gain rate. This attenuation is associated with reduced graft IL‐15 expression. n‐3 PUFA contributed to improved pathological and clinical outcome during chronic small bowel allograft rejection, and this improvement was associated with reduced graft IL‐15 expression.
影响因子：
4.4
作者：
Xian Chang Li;Prabir Roy-Chaudhury;Wayne W. Hancock;R. Manfro;Martin S. Zand;Yongsheng Li;X. Zheng;Peter W. Nickerson;Jürg Steiger;T. Malek;Terry B. Strom
通讯作者：
Xian Chang Li;Prabir Roy-Chaudhury;Wayne W. Hancock;R. Manfro;Martin S. Zand;Yongsheng Li;X. Zheng;Peter W. Nickerson;Jürg Steiger;T. Malek;Terry B. Strom
影响因子：
6.2
作者：
Adams,DH;Tilney,NL;CollinsJr,JJ;Karnovsky,MJ
通讯作者：
Karnovsky,MJ