Health effects of exposure to nano-TiO2: a meta-analysis of experimental studies.
Health effects of exposure to nano-TiO2: a meta-analysis of experimental studies.
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DOI：
10.1186/1556-276x-8-51
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发表时间：
2013-01-25
影响因子：
--
通讯作者：
Wang B
中科院分区：
文献类型：
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作者：
Chang X;Zhang Y;Tang M;Wang B
本文旨在通过体外和短期动物实验的荟萃分析来研究纳米tio2的毒性及其对人体健康的潜在有害影响。根据1994 - 2011年纳入和排除标准检索数据。通过细胞和动物模型计算不同终点纳米tio2的联合毒性效应。从实验研究分析，除凋亡组外，其余50%以上呈阳性统计学意义，细胞毒性呈剂量依赖性，但大小依赖性不明显。纳米tio2通过不同暴露途径进入血液后，在肝、脾、肾、脑等几个重要器官中均有滞留，但靶器官的系数与动物模型相比略有改变。纳米tio2诱导细胞损伤可能与暴露大小和剂量有关。需要进一步的研究来证明纳米颗粒对人体有毒性作用，特别是在流行病学研究中。
The paper is aimed to investigate the toxicity of nano-TiO2 and its potential harmful impact on human health using meta-analysis of in vitro and short-time animal studies. Data were retrieved according to included and excluded criteria from 1994 to 2011. The combined toxic effects of nano-TiO2 were calculated by the different endpoints by cell and animal models. From analysis of the experimental studies, more than 50% showed positive statistical significance except the apoptosis group, and the cytotoxicity was in a dose-dependent but was not clear in size-dependent manner. Nano-TiO2 was detained in several important organs including the liver, spleen, kidney, and brain after entering the blood through different exposure routes, but the coefficient of the target organs was altered slightly from animal models. It is possible that nano-TiO2 can induce cell damage related to exposure size and dose. Further studies will be needed to demonstrate that nanoparticles have toxic effects on human body, especially in epidemiological studies.