AGING OF HUMAN BONE AND ARTICULAR-CARTILAGE COLLAGEN - CHANGES IN REDUCIBLE CROSS-LINKS AND THEIR PRECURSORS
AGING OF HUMAN BONE AND ARTICULAR-CARTILAGE COLLAGEN - CHANGES IN REDUCIBLE CROSS-LINKS AND THEIR PRECURSORS
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DOI：
10.1159/000212148
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发表时间：
1976-01-01
期刊：
影响因子：
3.5
通讯作者：
SASAKI, S
中科院分区：
文献类型：
--
作者：
FUJII, K;KUBOKI, Y;SASAKI, S
在3-89岁的整个寿命期间，跟踪人骨和关节软骨中可还原胶原交联、席夫碱及其前体的年龄依赖性变化。随着老化，还原席夫碱二羟基赖氨酸正亮氨酸显着减少，而己糖醇赖氨酸峰显着增加，在两种胶原。二羟基正亮氨酸，交联的前体，随着年龄的增长略有增加。羟赖氨酸正亮氨酸和赖氨酸正亮氨酸的变化相对较小。这些变化进行了讨论，在较高的年龄在两种胶原蛋白中观察到的不溶性增加。
The age-dependent changes in reducible collagen cross-links, Schiff bases and their precursors were followed for human bone and articular cartilage throughout the whole life span from 3-89 yr of age. With aging, the reduced Schiff bases dihydroxylysinonorleucine remarkably decreased while hexitollysine peaks increased significantly in both collagens. Dihydroxynorleucine, the precursor of the cross-link, increased slightly with age. Changes in hydroxylysinonorleucine and lysinonorleucine were comparatively small. These changes were discussed in relation to the increased insolubility observed in both collagens at higher age.