EFFECTS OF DIETARY SODIUM AND OF ACUTE SALINE INFUSION ON INTERRELATIONSHIP BETWEEN DOPAMINE EXCRETION AND ADRENERGIC ACTIVITY IN MAN
EFFECTS OF DIETARY SODIUM AND OF ACUTE SALINE INFUSION ON INTERRELATIONSHIP BETWEEN DOPAMINE EXCRETION AND ADRENERGIC ACTIVITY IN MAN
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DOI：
10.1172/jci107743
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发表时间：
1974-01-01
影响因子：
15.9
通讯作者：
KEISER, HR
中科院分区：
文献类型：
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作者：
ALEXANDER, RW;GILL, JR;KEISER, HR
饮食钠和生理盐水输注对尿多巴胺和去甲肾上腺素的影响和这些肾上腺素能活动的关系进行了测定。在7名正常受试者中，摄入9 meq钠，尿多巴胺和去甲肾上腺素分别为136±18（SE）和37.4±5.3 μg/天。当钠摄入量增加到209或259 meq/d时，尿多巴胺增加到195±20 μg/d（P<0.01），而尿去甲肾上腺素减少到21.1±3.0 μg/d（P<0.01）。7例受试者输注生理盐水后尿钠和尿多巴胺（从2.18±0.22 μg/20 min增加到2.79±0.19 μg/20 min，P<0.01）增加，但血浆多巴胺-β-羟化酶和尿去甲肾上腺素无明显下降。菊糖和对氨基马尿酸的清除率无明显变化，滤过分数相同。这些数据表明，增加饮食中的钠或输注生理盐水的结果在一个明显的减少肾上腺素能活性和增加尿多巴胺。因此，多巴胺的排泄似乎与肾上腺素能活性和平行钠排泄呈负相关。这些发现表明多巴胺和去甲肾上腺素在调节肾钠排泄中可能发挥作用。
The effects of dietary sodium and of saline infusion on urinary dopamine and norepinephrine and on the relationship of these catecholamines to adrenergic activity were determined. In seven normal subjects on a 9-meq sodium intake, urinary dopamine and norepinephrine were 136±18 (SE) and 37.4±5.3 μg/day, respectively. When sodium intake was increased to 209 or 259 meq/day, urinary dopamine increased to 195±20 μg/day (P<0.01) whereas urinary norepinephrine decreased to 21.1±3.0 μg/day (P<0.01). Infusion of saline in seven subjects increased sodium excretion and urinary dopamine (from 2.18±0.22 to 2.79±0.19 μg/20 min,P<0.01), but decreased plasma dopamine-β-hydroxylase by 33% and urinary norepinephrine insignificantly. The clearance of inulin andp-aminohippurate did not change significantly and filtration fraction was the same. The data indicate that an increase in dietary sodium or infusion of saline results in an apparent decrease in adrenergic activity and an increase in urinary dopamine. Dopamine excretion would thus appear to relate inversely to adrenergic activity and to parallel sodium excretion. These findings suggest a possible role for dopamine and norepinephrine in the regulation of renal sodium excretion.