A click chemistry approach to C3 symmetric, G-quadruplex stabilising ligands.
A click chemistry approach to C3 symmetric, G-quadruplex stabilising ligands.
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DOI：
10.1039/c005055e
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发表时间：
2010-06
影响因子：
3.2
通讯作者：
J. Moses;Dougal J. Ritson;Fengzhi Zhang;C. Lombardo;S. Haider;N. Oldham;S. Neidle
中科院分区：
文献类型：
--
作者：
J. Moses;Dougal J. Ritson;Fengzhi Zhang;C. Lombardo;S. Haider;N. Oldham;S. Neidle
利用铜催化的叠氮化物-炔烃‘点击’反应，设计并合成了一系列三氮唑G-四链结合配体。报道并讨论了配体稳定G-四链体的结果。
Described is the structure-based design and synthesis of a series of tris-triazole G-quadruplex binding ligands utilising the copper catalysed azide-alkyne 'click' reaction. The results of G-quadruplex stabilisation by the ligands are reported and discussed.