Glycated albumin is a useful glycation index for monitoring fluctuating and poorly controlled type 2 diabetic patients
Glycated albumin is a useful glycation index for monitoring fluctuating and poorly controlled type 2 diabetic patients
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DOI：
10.1007/s00592-010-0242-0
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发表时间：
2011-06-01
影响因子：
3.8
通讯作者：
Lee, Hyun Chul
中科院分区：
文献类型：
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作者：
Lee, Eun Young;Lee, Byung-Wan;Lee, Hyun Chul
糖化白蛋白（GA）被认为是糖尿病患者短期血糖监测的可靠标志物。我们调查了韩国2型糖尿病患者中GA的临床相关性以及GA与糖化血红蛋白（A1 c）的比值。在这项回顾性研究中，我们比较了1,038名韩国2型糖尿病患者的A1 c、GA和GA/A1 c比值，并分析了血糖指数与各种参数之间的关系。患者被分为两组：A1 c水平至少6个月波动不超过0.5%的稳定维持A1 c组和A1 c水平波动超过0.5%的不稳定维持A1 c组。两组血清GA与A1 c均呈显著相关。A1 c不稳定组空腹血糖和餐后血糖与GA相关，而A1 c稳定组空腹血糖和餐后血糖与A1 c相关。GA/A1 c比值随A1 c的增加而增加。餐后血糖和体重指数影响GA/A1 c比值。我们的数据表明，血清GA可能是一个更有用的糖化指数比A1 c监测血糖控制2型糖尿病患者的波动和血糖控制不佳的漂移。
Glycated albumin (GA) is recognized as a reliable marker for short-term glycemic monitoring in diabetic patients. We investigated the clinical relevance of GA and the ratio of GA to glycated hemoglobin (A1c) in Korean type 2 diabetic patients. In this retrospective study, we compared A1c, GA, and the GA/A1c ratio and analyzed the relationship between glycemic indices and various parameters in 1,038 Korean type 2 diabetic patients. The patients were divided into two groups: a stably maintained A1c group whose A1c levels did not fluctuate by more than 0.5% for at least 6 months and an unstably maintained A1c group whose A1c levels fluctuated by more than 0.5%. Serum GA was strongly correlated with A1c in both groups. Fasting plasma glucose and postprandial glucose were correlated with GA in unstably maintained A1c group, whereas they were correlated with A1c in stably maintained A1c group. The GA/A1c ratio tended to increase as A1c increased. Postprandial glucose and body mass index affected the GA/A1c ratio. Our data show that serum GA may be a more useful glycation index than A1c for monitoring glycemic control in type 2 diabetic patients with fluctuating and poorly controlled glycemic excursions.