Molecules of cell adhesion and extracellular matrix proteolysis in oral squamous cell carcinoma.
Molecules of cell adhesion and extracellular matrix proteolysis in oral squamous cell carcinoma.
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DOI：
10.14670/hh-25.917
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发表时间：
2010-07
影响因子：
2
通讯作者：
Zonggao Shi;M. Stack
中科院分区：
文献类型：
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作者：
Zonggao Shi;M. Stack
口腔鳞状细胞癌（OSCC）是口腔最常见的恶性肿瘤，其5年生存率很低，这在很大程度上是由于在最初诊断时存在转移性疾病。近年来，许多研究已经检查了口腔肿瘤微环境，以评估细胞外基质沉积和蛋白水解降解之间的潜在动态平衡，以及介导与基质粘附并调节组织凝聚力的细胞粘附分子。本文综述了口腔肿瘤微环境中的主要基质成分、粘附分子和蛋白水解酶，并总结了这些复杂分子在口腔肿瘤进展中的作用。
Oral squamous cell carcinoma (OSCC) is the most common malignancy of the oral cavity with a poor 5-year survival rate, due in large part to the presence of metastatic disease at initial diagnosis. In recent years, a number of studies have examined the oral tumor microenvironment to asses the potential dynamic balance between extracellular matrix deposition and proteolytic degradation as well as the cellular adhesion molecules that mediate adhesion to matrix and regulate tissue cohesion. The objective of this review is to provide a brief overview of the major matrix components, adhesion molecules and proteolytic enzymes in the oral tumor microenvironment and to summarize recent findings regarding the role of these complex molecular players in oral tumor progression.