Temporal Lobe Epileptogenesis and Epilepsy in the Developing Brain: Bridging the Gap Between the Laboratory and the Clinic. Progression, But in What Direction?
Temporal Lobe Epileptogenesis and Epilepsy in the Developing Brain: Bridging the Gap Between the Laboratory and the Clinic. Progression, But in What Direction?
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DOI：
10.1111/j.0013-9580.2003.12008.x
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发表时间：
2003-12
期刊：
影响因子：
5.6
通讯作者：
L. Velíšek;Solomon L. Moshé
中科院分区：
文献类型：
--
作者：
L. Velíšek;Solomon L. Moshé
摘要：人类内侧颞叶癫痫和海马硬化的起源仍然没有很好的理解。海马硬化和颞叶癫痫发生涉及海马神经元丢失和胶质增生、轴突重组以及可能的海马神经元发生等一系列病理过程。然而，这些事件的因果关系及其与可能诱发癫痫发生的因素的关系尚不清楚。成人和未成熟大脑颞叶癫痫发生之间的显著差异可能需要不同的方法。遗传因素也可能参与海马硬化的某些病例。关键是要确定这些年龄依赖性变化的意义，并设计预防性治疗。预防和治疗内侧颞叶癫痫和海马硬化的新策略可能包括合理使用神经保护剂，神经保护疗法，免疫接种和免疫治疗。
Summary: The origins of human mesial temporal lobe epilepsy and hippocampal sclerosis are still not well understood. Hippocampal sclerosis and temporal lobe epileptogenesis involve a series of pathologies including hippocampal neuronal loss and gliosis, axonal reorganization, and maybe hippocampal neoneurogenesis. However, the causality of these events is unclear as well as their relation to the factors that may precipitate epileptogenesis. Significant differences between temporal lobe epileptogenesis in the adult and immature brain may require differential approaches. Hereditary factors also may participate in some cases of hippocampal sclerosis. The key point is to identify the significance of these age‐dependent changes and to design preventive treatments. Novel strategies for the prevention and treatment of mesial temporal lobe epilepsy and hippocampal sclerosis may include rational use of neuroprotective agents, hormonotherapy, immunizations, and immunotherapy.