A comparison of multiple urine markers for interstitial cystitis
A comparison of multiple urine markers for interstitial cystitis
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DOI：
10.1016/s0022-5347(05)65005-7
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发表时间：
2002-06-01
影响因子：
6.6
通讯作者：
Keay, SK
中科院分区：
文献类型：
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作者：
Erickson, DR;Xie, SX;Keay, SK
目的：我们检测了间质性膀胱炎患者和健康对照者24小时尿液中的几种标志物。对于每个标记物，我们确定是否尿水平显着不同的间质性膀胱炎和对照cases，以及是否标记物水平与症状scores.Materials和方法：研究参与者包括36名女性间质性膀胱炎患者和36名年龄匹配的女性志愿者。获得多个尿液等分试样来测量各种markets.Results：某些标志物显着增加间质性膀胱炎，包括抗增殖因子，表皮生长因子，胰岛素样生长因子（IGF）结合蛋白-3和白细胞介素（IL）-6。间质性膀胱炎显著降低的标志物是肝素结合表皮生长因子样生长因子、环磷酸鸟苷和甲基组胺。其他标志物在间质性膀胱炎组和对照组中没有显著差异，包括总糖胺聚糖、epitectin、透明质酸、IL-8、IL-1和硝酸盐加亚硝酸盐。IGF-1在24小时尿液样本中检测不到，但来自同一间质性膀胱炎人群的点排泄样本的IGF-1水平与先前报道的水平相似。标志物与症状评分的唯一显著关联是IL-6与腹泻的正相关。对于所有的标志物的结论是相同的标志物是否正常化到肌酐或24 hours.Conclusions：本研究证实了一些以前报道的尿改变间质性膀胱炎，包括增加抗增殖因子，表皮生长因子，IGF结合蛋白-3和IL-6，并减少肝素结合表皮生长因子样生长因子和环磷酸鸟苷。在研究的所有标记物中，抗增殖因子在间质性膀胱炎和对照组中重叠最少，因此它最有可能成为诊断测试的候选者。
Purpose: We measured several urine markers in 24-hour specimens from patients with interstitial cystitis and healthy controls. For each marker we determined whether the urine level was significantly different in interstitial cystitis and control cases, and whether the marker level correlated with the symptom score.Materials and Methods: Study participants included 36 female patients with interstitial cystitis and 36 age matched female volunteers. Multiple urine aliquots were obtained to measure the various markers.Results: Certain markers were significantly increased in interstitial cystitis, including antiproliferative factor, epidermal growth factor, insulin-like growth factor (IGF) binding protein-3 and interleukin (IL)-6. Markers significantly decreased in interstitial cystitis were heparin-binding epidermal growth factor-like growth factor, cyclic guanosine monophosphate and methylhistamine. Other markers were not significantly different in the interstitial cystitis and control groups, including total glycosaminoglycans, epitectin, hyaluronic acid, IL-8, IL-1 and nitrates plus nitrites. IGF-1 was undetectable in 24-hour urine samples but spot voided samples from the same interstitial cystitis population had IGF-1 levels similar to previously reported levels. The only significant association of marker with symptom score was a positive correlation of IL-6 with nocturia. For all markers the conclusions were the same whether the marker was normalized to creatinine or to 24 hours.Conclusions: This study confirmed several previously reported urine alterations in interstitial cystitis, including increased anti-proliferative factor, epidermal growth factor, IGF binding protein-3 and IL-6, and decreased heparin-binding epidermal growth factor-like growth factor and cyclic guanosine monophosphate. Of all markers studied anti-proliferative factor had the least overlap in the interstitial cystitis and control groups, and so it is the most likely candidate to become a diagnostic test.