Conflicts of Interest in Clinical Guidelines: Update of US Preventive Services Task Force Policies and Procedures
Conflicts of Interest in Clinical Guidelines: Update of US Preventive Services Task Force Policies and Procedures
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DOI：
10.1016/j.amepre.2017.06.034
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发表时间：
2018-01-01
影响因子：
5.5
通讯作者：
Bibbins-Domingo, Kirsten
中科院分区：
文献类型：
--
作者：
Ngo-Metzger, Quyen;Moyer, Virginia;Bibbins-Domingo, Kirsten
美国预防服务工作组（USPSTF）为临床预防服务提供独立，客观和科学严谨的建议。一个主要的关切是，甚至要避免出现有特殊利益的成员，因为这种利益可能影响他们判断证据和提出公正建议的能力。利益冲突的政策USPSTF的描述，是正式的过程中，最佳实践被纳入更新的政策。USPSTF进行了文献综述，进行了关键的线人访谈，并审查了利益冲突政策往往类似的组织。重要的调查结果包括透明度和公众可获得性;充分披露财务关系;披露非财务关系（可能产生偏见并损害成员的客观判断）;披露家庭成员的利益冲突;以及确定适当的报告期。最佳做法方面的争议包括财务披露的门槛、获取利益冲突政策和声明的难易程度、非财务偏见的模糊定义以及要求家庭成员提供利益冲突（特别是非财务性质的利益冲突）。USPSTF的利益冲突政策包括对直系亲属的披露，明确的非财务利益冲突定义，长期回顾期以及对潜在成员的政策应用。每4个月向所有成员征求利益冲突，正式审查，裁定，并公开提供。USPSTF利益冲突政策作为USPSTF程序手册的一部分公开提供。一个持续改进的过程可以应用于利益冲突政策，以提高公众对小组成员的信任，如USPSTF，产生临床指南和建议。(c)2017年美国预防医学杂志。爱思唯尔公司出版
The U.S. Preventive Services Task Force (USPSTF) provides independent, objective, and scientifically rigorous recommendations for clinical preventive services. A primary concern is to avoid even the appearance of members having special interests that might influence their ability to judge evidence and formulate unbiased recommendations. The conflicts of interest policy for the USPSTF is described, as is the formal process by which best practices were incorporated to update the policy. The USPSTF performed a literature review, conducted key informant interviews, and reviewed conflicts of interest policies often similar organizations. Important findings included transparency and public accessibility; full disclosure of financial relationships; disclosure of non-financial relationships (that create the potential for bias and compromise a member's objective judgment); disclosure of family members' conflicts of interests; and establishment of appropriate reporting periods. Controversies in best practices include the threshold of financial disclosures, ease of access to conflicts of interest policies and declarations, vague definition of non-financial biases, and request for family members' conflicts of interests (particularly those that are non-financial in nature). The USPSTF conflicts of interest policy includes disclosures for immediate family members, a clear non-financial conflicts of interest definition, long look-back period and application of the policy to prospective members. Conflicts of interest is solicited from all members every 4 months, formally reviewed, adjudicated, and made publicly available. The USPSTF conflicts of interest policy is publicly available as part of the USPSTF Procedure Manual. A continuous improvement process can be applied to conflicts of interest policies to enhance public trust in members of panels, such as the USPSTF, that produce clinical guidelines and recommendations. (c) 2017 American Journal of Preventive Medicine. Published by Elsevier Inc.