Serum levels of albumin, triglycerides, total protein and glucose in rats are altered after oral treatment with low doses of 13-cis-retinoic acid or all-trans-retinoic acid
Serum levels of albumin, triglycerides, total protein and glucose in rats are altered after oral treatment with low doses of 13-cis-retinoic acid or all-trans-retinoic acid
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DOI：
10.1002/jat.1082
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发表时间：
2005-11-01
影响因子：
3.3
通讯作者：
Ferguson, SA
中科院分区：
文献类型：
--
作者：
Cisneros, FJ;Gough, BJ;Ferguson, SA
目前用于治疗严重痤疮，13-顺式-视黄酸（13-cis-RA）正在研究其抗癌作用，其异构体全反式-视黄酸（all-trans-RA）也是如此。在这里，口服13-顺式-RA或全反式-RA治疗对血清化学，瘦素和脂联素水平的影响进行了评估。成年Sprague-Dawley大鼠连续7天每天一次灌胃13-顺式-RA（7.5或15 mg kg（-1））、全反式-RA（10或15 mg kg（-1））（n = 24/性别/剂量）或豆油（n = 16/性别），并在最后一次灌胃后30-480 min采集血样。体重未受影响;然而，两种剂量的全反式RA均增加了肝脏/体重比。胆固醇、肌酸、甘油三酯、白蛋白、丙氨酸氨基转移酶和总蛋白水平存在性别差异。两种剂量的全反式RA均使白蛋白水平降低至对照的约90%，总蛋白水平降低至对照的约93%，同时使甘油三酯水平显著升高至对照的约66%-99%。此外，本发明还15 mg kg（-1）13-cis-RA组的甘油三酯水平比对照组高约62%，总蛋白水平比对照组低约5%。葡萄糖水平受性别和RA治疗的影响，15 mg kg（-1）13-cis-RA或10 mg kg（-1）全反式RA治疗的雄性动物葡萄糖水平比对照组低（13%-19%）。水平高于同性别对照组;然而，女性没有受到类似的影响。13-顺式-RA和全反式-RA治疗对血尿素氮、天冬氨酸氨基转移酶、瘦素或脂联素水平均无显着影响。在mg kg（-1）的基础上，alltrans-RA比13-cis-RA更有效。这些结果重复了先前RA诱导的甘油三酯水平升高的发现。此外，一些新的研究结果表明，RA治疗可能存在性别特异性效应。最后，两种治疗似乎都没有改变这些终点的典型昼夜周期。版权所有（c）2005年约翰威利父子有限公司。
Currently used to treat severe acne, 13-cis-retinoic acid (13-cis-RA) is under investigation for its anticancer effects as is the isomer, all-trans-retinoic acid (all-trans-RA). Here, the effects of oral 13-cis-RA or all-trans-RA treatment on serum chemistry, leptin and adiponectin levels were evaluated. Adult Sprague-Dawley rats were gavaged once daily for 7 consecutive days with 13-cis-RA (7.5 or 15 mg kg(-1)), all-trans-RA (10 or 15 mg kg(-1)) (n = 24/sex/dose), or soy oil (n = 16/sex) and blood was sampled 30-480 min after the last gavage. The body weight was unaffected; however, the liver/ body weight ratios were increased by both doses of all-trans-RA. Sex differences were noted for levels of cholesterol, creatine, triglycerides, albumin, alanine aminotransferase and total protein. Both doses of all-trans-RA reduced albumin levels to approximate to 90% of the control and total protein levels to approximate to 93% of the control while substantially elevating triglyceride levels to approximate to 66%-99% above the control. Additionally, triglyceride levels of the 15 mg kg(-1) 13-cis RA group were approximate to 62% higher than the controls and total protein levels were approximate to 5% less. Glucose levels were affected by sex and RA treatment in that males treated with 15 mg kg(-1) of 13-cis-RA or 10 mg kg(-1) all-trans-RA had lower (13%-19%) levels than the same- sex controls; however, females were not similarly affected. Neither 13-cis-RA nor all-trans-RA treatment had significant effects on the levels of blood urea nitrogen, aspartate amino transferase, leptin or adiponectin. On a mg kg(-1) basis, alltrans-RA was more potent than 13-cis-RA. These results replicate previous findings of RA-induced increased triglyceride levels. Additionally, several new findings indicate there may be sex-specific effects of RA treatment. Finally, neither treatment appeared to alter the typical diurnal cycles of these endpoints. Copyright (c) 2005 John Wiley & Sons, Ltd.