Effects of exercise on angiogenesis and apoptosis-related molecules, quality of life, fatigue and depression in breast cancer patients
Effects of exercise on angiogenesis and apoptosis-related molecules, quality of life, fatigue and depression in breast cancer patients
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DOI：
10.1111/ecc.12068
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发表时间：
2013-09-01
影响因子：
2.1
通讯作者：
Uslu, R.
中科院分区：
文献类型：
--
作者：
Ergun, M.;Eyigor, S.;Uslu, R.
本研究的目的是探讨运动对完成乳腺癌治疗的患者的血管生成和乳腺癌相关分子、生活质量、疲劳和抑郁的影响。将60例乳腺癌患者随机分为3组，即指导运动组、家庭运动组和教育组。在12周的运动计划之前和之后，比较了血管生成和凋亡相关的细胞因子水平和生活质量（EORTC QOL-C30：欧洲癌症研究和治疗组织生活质量C30），疲劳（简明疲劳量表）和抑郁（BDI：贝克抑郁量表）评分。运动后，家庭运动组IL-8和中性粒细胞活化蛋白-78水平显著降低（P < 0.05）。受教育组单核细胞趋化蛋白-1水平显著高于对照组（P < 0.05）。指导运动组EORTC QOL-C30功能评分、总体健康评分和家庭运动组EORTC QOL-C30功能评分在运动后显著提高（P < 0.05）。指导运动组运动后BDI评分显著低于对照组（P < 0.05）。研究组中血管生成和骨质疏松相关分子的变化表明运动可能对这些参数产生影响。运动计划对治疗完成的乳腺癌患者的生活质量和抑郁症是安全有效的。
The aim of this study was to explore the effects of exercise on angiogenesis and apoptosis-related molecules, quality of life, fatigue and depression in patients who completed breast cancer treatment. Sixty breast cancer patients were randomised into three groups, as supervised exercise group, home exercise group and education group. Angiogenesis and apoptosis-related cytokine levels and quality of life (EORTC QOL-C30: European Organisation for Research and Treatment of Cancer Quality of Life C30), fatigue (Brief Fatigue Inventory) and depression (BDI: Beck Depression Inventory) scores were compared before and after a 12-week exercise programme. After the exercise programme, statistically significant decreases were found in interleukin-8 and neutrophil activating protein-78 levels in the home exercise group (P < 0.05). The education group showed a statistically significant increase in monocyte chemoattractant protein-1 level (P < 0.05). Functional score and global health score of EORTC QOL-C30 in the supervised exercise group and functional score of EORTC QOL-C30 in the home exercise group increased significantly after exercise programme (P < 0.05). BDI score was significantly lower in the supervised exercise group after the exercise programme (P < 0.05). Changes in angiogenesis and apoptosis-related molecules in the study groups suggest a possible effect of exercise on these parameters. Exercise programmes are safe and effective on quality of life and depression in breast cancer patients whose treatments are complete.