A survey of semen indices in insecticide sprayers
A survey of semen indices in insecticide sprayers
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DOI：
10.1539/joh.46.109
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发表时间：
2004-03-01
影响因子：
3
通讯作者：
Takeuchi, Y
中科院分区：
文献类型：
--
作者：
Kamijima, M;Hibi, H;Takeuchi, Y
杀虫剂喷雾器精液指标调查：神岛美智弘等。名古屋大学大学院医学部职业与环境健康学部--这项研究旨在澄清主要接触有机磷和拟除虫菊酯杀虫剂的杀虫剂喷雾者的精液指数。在日本中部的9家公司工作的54名男性喷雾员中，有18名参加了夏季和次年冬季的详细生殖检查，另有18名年龄匹配的学生或医生作为未暴露在空气中的对照组。喷雾器在夏季(最繁忙的季节)比冬季(淡季)更容易接触到杀虫剂(p<；0.05)。夏季，喷雾者的红细胞真胆碱酯酶活性低于对照组(p<；0.05)，且随暴露频率的增加而显著降低。喷雾剂组的睾丸体积明显小于对照组(p=0.06)。冬季喷雾者的血清睾酮浓度高于对照组(p<；0.05)，但黄体生成素和卵泡刺激素的浓度没有显著差异。两组的精子数量和活力相似，但夏季详细的精子运动分析显示，喷雾器中缓慢前进和非前进运动精子的百分比是喷雾器的两倍(p<；0.05)，而快速前进精子的百分比则更低(p=0.06)。这种差异在冬季没有观察到。精子形态分类计数显示，只有在夏季体检时，形态正常的精子和头部畸形的精子才有明显的群体交互作用和禁欲效应。尽管两组之间可能存在内在差异，但上述随季节变化的差异表明，喷雾器中观察到的较低的精液质量与农药喷洒工作有关。
A Survey of Semen Indices in Insecticide Sprayers: Michihiro Kamijima, et al. Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine-This study aims at clarifying the semen indices of insecticide sprayers who are exposed mainly to organophosphorus and pyrethroid insecticides. Eighteen male sprayers out of 54 working for 9 companies in central Japan and 18 age-matched students or medical doctors as unexposed controls participated in detailed reproductive check-ups conducted in summer and the following winter. The sprayers were exposed to insecticides more in summer, the busiest season, than winter, the off-season (p < 0.05). Erythrocyte true cholinesterase activities in the sprayers were lower than in the controls in summer (p < 0.05), and decreased in significant association with the increase in exposure frequency. Testicular volumes in the sprayers tended to be smaller than in the controls (p = 0.06). The serum testosterone concentration in winter in the sprayers was higher than in the controls (p < 0.05), though luteinizing hormone and follicle stimulating hormone concentrations were not significantly different. The sperm counts and vitality were comparable between the groups, but detailed sperm motility analysis in summer revealed that the percentages of slow progressive and nonprogressive motile sperm were twice as high in the sprayers (p < 0.05), and that of rapid progressive sperm tended to be lower (p = 0.06). Such differences were not observed in winter. Differential sperm morphology counts showed that interaction of group and abstinence effects were significant in sperm with normal morphology and with head deformity only in the summer check-up. Despite possible inherent differences between the groups, the above season-dependent differences suggested that the observed lower semen quality in the sprayers was associated with pesticide spraying work.