Helium ions versus iodine 125 brachytherapy in the management of uveal melanoma. A prospective, randomized, dynamically balanced trial.
Helium ions versus iodine 125 brachytherapy in the management of uveal melanoma. A prospective, randomized, dynamically balanced trial.
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氦离子与碘 125 近距离放射治疗治疗葡萄膜黑色素瘤。
DOI：
10.1016/s0161-6420(93)31446-6
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发表时间：
1993
期刊：
影响因子：
13.7
通讯作者：
Phillips,T
中科院分区：
文献类型：
--
作者：
Char,DH;Quivey,JM;Castro,JR;Kroll,S;Phillips,T
目的：葡萄膜黑色素瘤的最佳放射治疗是不确定的，放射性斑块和带电粒子的相对efficacies是unclear.Methods：作者前瞻性地研究了氦离子照射和碘125（125 I）近距离放射治疗的随机，动态平衡试验。在184例符合入选标准的患者中，86例接受氦离子治疗，98例接受1251近距离放射治疗。肿瘤最大直径小于15 mm，厚度小于10 mm。将70 GyE的最小肿瘤剂量递送至肿瘤顶端。1251近距离放射治疗后局部复发率明显高于氦离子照射后。近距离放射治疗后眼球摘除发生率更高（相对风险= 1.99; 95%置信区间，0.78-5.78）。氦离子照射后眼前节并发症较多。到目前为止，已经没有可测量的影响survival.Conclusions：大多数葡萄膜黑色素瘤可以管理与保留的眼睛辐射。氦离子照射有更好的肿瘤控制，但是，有更多的眼前节并发症。
Purpose:Optimal radiation therapy for uveal melanoma is uncertain, and the relative efficacies of radioactive plaques and charged particles are unclear.Methods:The authors prospectively studied helium-ion irradiation and iodine 125 (125I) brachytherapy in a randomized, dynamically balanced trial. Of the 184 patients who met the eligibility criteria, 86 were treated with helium ions and 98 with1251 brachytherapy.Results:No patients with uveal melanoma had a history of systemic malignancy. Tumors were less than 15 mm in maximum diameter and less than 10 mm in thickness. A minimum tumor dose of 70 GyE was delivered to the tumor apex. There was a significantly higher local recurrence rate after1251 brachytherapy than after helium-ion irradiation. Enucleations occurred more frequently after brachytherapy (relative risk = 1.99; 95% confidence interval, 0.78–5.78). More anterior segment complications occurred after helium-ion irradiation. To date, there has been no measurable impact on survival.Conclusions:Most uveal melanomas can be managed with radiation with retention of the eye. There was better tumor control with helium-ion irradiation; however, there were more anterior segment complications.