Cajal-retzius cells: Recent advances in identity and function
Cajal-retzius cells: Recent advances in identity and function
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DOI：
10.1016/j.conb.2023.102686
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发表时间：
2023-02-10
影响因子：
5.7
通讯作者：
Causeret，Frederic
中科院分区：
文献类型：
--
作者：
Elorriaga，Vicente;Pierani，Alessandra;Causeret，Frederic
Cajal-Retzius细胞（CRs）是发育中的大脑皮层的一种瞬时神经元类型。多年来，它们已被证明或提出在新皮层和海马的形态发生、电路形成、大脑进化和人类病理中发挥重要作用。由于寿命短，CRs被认为是一种纯粹的发育细胞类型，其产生和主动消除都是大脑正常发育所必需的。在这篇综述中，我们提出了一些发现，使我们能够更好地了解这种非常特殊的细胞类型的身份和多样性，并提出了什么应该被认为是Cajal-Retzius细胞的统一定义，特别是在与非哺乳动物物种或类器官一起工作时。此外，我们强调了最近的一系列研究，指出cr在功能和功能失调的皮层网络组装中的重要性。
Cajal-Retzius cells (CRs) are a transient neuronal type of the developing cerebral cortex. Over the years, they have been shown or proposed to play important functions in neocortical and hippocampal morphogenesis, circuit formation, brain evolution and human pathology. Because of their short lifespan, CRs have been pictured as a purely developmental cell type, whose production and active elimination are both required for correct brain development. In this review, we present some of the findings that allow us to better appreciate the identity and diversity of this very special cell type, and propose a unified definition of what should be considered a Cajal-Retzius cell, especially when working with non-mammalian species or organoids. In addition, we highlight a flurry of recent studies pointing to the importance of CRs in the assembly of functional and dysfunctional cortical networks.