Hyaluronan-modified magnetic nanoclusters for detection of CD44-overexpressing breast cancer by MR imaging
Hyaluronan-modified magnetic nanoclusters for detection of CD44-overexpressing breast cancer by MR imaging
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DOI：
10.1016/j.biomaterials.2011.06.077
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发表时间：
2011-11-01
期刊：
影响因子：
14
通讯作者：
Haam, Seungjoo
中科院分区：
文献类型：
--
作者：
Lim, Eun-Kyung;Kim, Hyun-Ouk;Haam, Seungjoo
我们制作了透明质酸修饰的磁性纳米团簇（HA-MNCs），用于磁共振（MR）成像检测过表达cd44的乳腺癌。CD44与肿瘤生长密切相关，包括增殖、转移、侵袭和血管生成。因此，我们用透明质酸（HA）和1-芘基丁酸（Py）合成了芘基透明质酸（Py-HA）缀合物作为cd44靶向表面活性剂，在疏水磁性纳米晶体上修饰透明质酸。随后。采用纳米乳液法制备HA-MNCs；磁性纳米晶体与Py- ha共轭物同时自组装，其物理和磁性能取决于Py- ha共轭物中Py的取代度（DS）。通过体外/体内研究，HA-MNCs表现出优异的靶向效率和MR敏感性，以及良好的生物相容性。这表明HA-MNCs可以通过MR成像靶向检测CD44成为一种有效的癌症特异性分子显像剂。爱思唯尔有限公司版权所有版权所有。
We fabricated hyaluronan-modified magnetic nanoclusters (HA-MNCs) for detection of CD44-overexpressing breast cancer using magnetic resonance (MR) imaging. CD44 is closely associated with cancer growth, including proliferation, metastasis, invasion, and angiogenesis. Hence, pyrenyl hyaluronan (Py-HA) conjugates were synthesized as CD44-targetable surfactants with hyaluronan (HA) and 1-pyrenylbutyric acid (Py) to modify hyaluronan on hydrophobic magnetic nanocrystals. Subsequently. HA-MNCs were fabricated using the nano-emulsion method; magnetic nanocrystals were simultaneously self-assembled with Py-HA conjugates, and their physical and magnetic properties depended on the degree of substitution (DS) of Py in Py-HA conjugates. HA-MNCs exhibited superior targeting efficiency with MR sensitivity as well as excellent biocompatibility through in vitro/in vivo studies. This suggests that HA-MNCs can be a potent cancer specific molecular imaging agent via targeted detection of CD44 with MR imaging. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.