ISLET CELL AND THYROGASTRIC ANTIBODIES IN 633 CONSECUTIVE 15-YR-OLD TO 34-YR-OLD PATIENTS IN THE DIABETES INCIDENCE STUDY IN SWEDEN
ISLET CELL AND THYROGASTRIC ANTIBODIES IN 633 CONSECUTIVE 15-YR-OLD TO 34-YR-OLD PATIENTS IN THE DIABETES INCIDENCE STUDY IN SWEDEN
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DOI：
10.2337/diabetes.41.8.1022
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发表时间：
1992-08-01
期刊：
影响因子：
7.7
通讯作者：
OSTMAN, J
中科院分区：
文献类型：
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作者：
LANDINOLSSON, M;KARLSSON, FA;OSTMAN, J
在 633 名连续诊断的 15-34 岁瑞典糖尿病患者和 282 名同龄志愿者中评估了年龄对 IDDM 诊断时 ICA 和甲状腺胃抗体的影响。 61%（633 名中的 383 名）患者和 2%（282 名中的 5 名）对照受试者存在 ICA。当考虑初始分类时，69%（473 名中的 327 名）IDDM 患者、23%（83 名中的 19 名）NIDDM 患者、50%（72 名中的 36 名）未分类糖尿病患者以及 20%（5 名中的 1 名继发性糖尿病患者）检测到 ICA。随着 IDDM 患者年龄的增长，ICA 频率显着下降 (P < 0.001)，从 15-19 岁 IDDM 患者的 77% (104/135) 降至 30-34 岁 IDDM 患者的 52% (96 人中的 50 人)。 30 至 34 岁 IDDM 患者中 ICA 发生率较低的仅限于男性（42%，66 名患者中的 28 名）。 IDDM 患者（10%，449 例中的 47 例）胃（H+、K+-ATPase）抗体的频率显着（P < 0.05）高于 NIDDM 患者（3%，80 例中的 3 例）和无法分类的糖尿病患者（4%，72 例中的 3 例）。 总之，年轻成人受试者中 ICA 诊断 IDDM 的频率随着年龄的增长而降低，尤其是男性。 在被认为患有 NIDDM 或无法分类的糖尿病的患者中频繁发现 ICA 表明，在最近诊断为糖尿病的年轻成年患者中，糖尿病的错误分类很常见。
The effect of age on ICA and thyrogastric antibodies at diagnosis of IDDM was evaluated in 633 consecutively diagnosed Swedish diabetic patients aged 15-34 yr and in 282 volunteers of the same age. ICAs were present in 61% (383 of 633) of the patients and in 2% (5 of 282) of control subjects. When the initial classification was considered, ICAs were detected in 69% (327 of 473) of patients with IDDM, 23% (19 of 83) of those with NIDDM, 50% (36 of 72) of those with unclassifiable diabetes, and 20% (1 of 5) of those with secondary diabetes. The frequency of ICA fell significantly (P < 0.001) with age in IDDM patients from 77% (104/135) in those 15-19 yr old to 52% (50 of 96) in 30- to 34-yr-old IDDM patients. The low frequency of ICA in 30- to 34-yr-old IDDM patients was confined to men (42%, 28 of 66). The frequency of gastric (H+, K+-ATPase) antibodies was significantly (P < 0.05) higher in IDDM patients (10%, 47 of 449) than in patients with NIDDM (3%, 3 of 80) and unclassifiable diabetes (4%, 3 of 72). In conclusion, the frequency of ICA at the diagnosis of IDDM in young adult subjects decreases with increasing age, particularly in men. The frequent finding of ICA in patients considered to have NIDDM or unclassifiable diabetes indicates that misclassification of diabetes is frequent in young adult patients recently diagnosed with diabetes.