[Each one case of Vogt-Koyanagi-Harada disease with vestibular and cerebellar ataxia, and multiple cranial nerve palsies].
[Each one case of Vogt-Koyanagi-Harada disease with vestibular and cerebellar ataxia, and multiple cranial nerve palsies].
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伴有前庭和小脑共济失调、多发性颅神经麻痹的 Vogt-Koyanagi-Harada 病各 1 例。
DOI：
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发表时间：
1989
期刊：
影响因子：
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通讯作者：
T. Kuboshiro
中科院分区：
文献类型：
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作者：
Y. Hiraki;N. Kuwasaki;H. Shoji;M. Kaji;T. Kuboshiro
报告2例Vogt-小柳-原田病的罕见神经系统并发症，其中1例为前庭和小脑共济失调，1例为多发性脑神经麻痹。第一个病例是一位32岁的男性，因为视力受损而住进我们的眼科。两周后，他主诉步态障碍。观察肢体和躯干共济失调、前庭功能障碍和感觉性耳聋。眼科检查显示典型的伏格特-小柳-原田病的结果。CSF显示蛋白升高和单核细胞增多。口服类固醇治疗后，前庭和小脑共济失调，视力障碍改善。第二个病例是一名22岁的男性，显示第VII、VIII、IX和X脑神经麻痹伴视力障碍，他被诊断为与Vogt-Koyanagi-Harada病相关的脑神经麻痹。类固醇治疗后，有一个显着的临床改善。Vogt-Koyanagi-Harada病是一种针对黑素细胞的自身免疫性疾病，累及葡萄膜、脑膜、皮肤和内耳等含有黑素细胞的组织。在日本，除了脑膜炎和感知性耳聋之外，很少报告神经系统并发症。结合目前的病例，讨论了可能的发病机制。
Two cases of Vogt-Koyanagi-Harada disease with rare neurological complications were reported, which are one case with vestibular and cerebellar ataxia, and one with multiple cranial nerve palsies. The first case, a 32-year-old man, was admitted to our ophthalmologic department because of visual impairment. Two weeks later, he complained of gait disturbance. Limb and truncal ataxia, vestibular dysfunction and perceptive deafness were observed. Ophthalmologic examination revealed typical findings of Vogt-Koyanagi-Harada disease. CSF showed elevated protein and mononuclear pleocytosis. After treatment with oral steroid therapy, vestibular and cerebellar ataxia, and visual impairment improved. The second case, a 22-years-old man, showed the VIIth, VIIIth, IXth, and Xth cranial nerve palsies with visual impairment, and he was diagnosed to have cranial nerve palsies associated with Vogt-Koyanagi-Harada disease. After steroid therapy, there was a marked clinical improvement. Vogt-Koyanagi-Harada disease is an autoimmune disease against the melanocytes and involving tissues containing melanocytes such as uvea, meningea, skin and inner ear, etc.. Neurological complications except for meningitis and perceptive deafness have been rarely reported in Japan. Related to the present cases, possible pathogenesis was discussed.