BROWN ADIPOSE CELLS - SPONTANEOUS MOBILIZATION OF ENDOGENOUSLY SYNTHESIZED LIPID
BROWN ADIPOSE CELLS - SPONTANEOUS MOBILIZATION OF ENDOGENOUSLY SYNTHESIZED LIPID
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DOI：
10.1126/science.163.3864.288
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发表时间：
1969-01-01
期刊：
影响因子：
56.9
通讯作者：
ANGEL, A
中科院分区：
文献类型：
--
作者：
ANGEL, A
分离的棕色脂肪细胞没有基底膜，很容易从放射性醋酸酯中合成各种脂类，这种反应在葡萄糖和胰岛素的作用下得到加强。新形成的脂肪酸中有很大一部分进入了培养基中。在完整的棕色脂肪切片和分离的白色脂肪细胞中，大部分合成的脂肪以甘油酯的形式保留。这些数据表明，在对完整组织切片的研究中，棕色脂肪细胞内源性合成脂肪的快速周转几乎完全被掩盖，因为组织间隙屏障阻止了脂肪酸的排出。
Isolated brown adipose cells, devoid of a basement membrane, readily synthesized a variety of lipids from radioactive acetate, a reaction augmented by glucose and insulin. A large proportion of the newly formed fatty acids passed into the incubation medium. In intact brown adipose slices and isolated white adipose cells, most of the synthesized lipid was retained as glyceride esters. The data suggest that the rapid turnover of endogenously synthesized lipid in brown adipose cells is almost totally obscured in studies with intact tissue slices because of interstitial barriers to the egress of fatty acid.