Physical aspects of heterogeneities in multi-component lipid membranes
Physical aspects of heterogeneities in multi-component lipid membranes
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DOI：
10.1016/j.cis.2013.12.003
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发表时间：
2014-06-01
影响因子：
15.6
通讯作者：
Andelman, David
中科院分区：
文献类型：
--
作者：
Komura, Shigeyuki;Andelman, David
生物膜筏模型的提出改变了传统的基于流体镶嵌模型的生物膜观。在筏模型中，多组分脂双层的动力学不均匀性起着至关重要的作用。本文着重于生物膜和囊泡的侧向相分离，回顾了近十年来相关的研究进展。我们主要是指那些基于物理化学方法的实验工作，并在软物质物理方面给出的理论解释。在第一部分中，我们描述了多组分脂双层膜的相行为和构象。在建立了流体膜在周围溶剂存在下的流体力学方程后，我们讨论了畴生长规律和浓度涨落的衰减速率。最后，我们回顾了几种试图将膜筏描述为二维微乳液。(C)2013爱思唯尔有限公司版权所有。
Ever since the raft model for biomembranes has been proposed, the traditional view of biomembranes based on the fluid-mosaic model has been altered. In the raft model, dynamical heterogeneities in multi-component lipid bilayers play an essential role. Focusing on the lateral phase separation of biomembranes and vesicles, we review some of the most relevant research conducted over the last decade. We mainly refer to those experimental works that are based on physical chemistry approach, and to theoretical explanations given in terms of soft matter physics. In the first part, we describe the phase behavior and the conformation of multi-component lipid bilayers. After formulating the hydrodynamics of fluid membranes in the presence of the surrounding solvent, we discuss the domain growth-law and decay rate of concentration fluctuations. Finally, we review several attempts to describe membrane rafts as two-dimensional microemulsion. (C) 2013 Elsevier B.V. All rights reserved.