DITERPENE METABOLITES FROM 2 CHEMOTYPES OF THE MARINE SPONGE MYRMEKIODERMA-STYX
DITERPENE METABOLITES FROM 2 CHEMOTYPES OF THE MARINE SPONGE MYRMEKIODERMA-STYX
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DOI：
10.1021/np50088a006
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发表时间：
1992-10-01
影响因子：
5.1
通讯作者：
WRIGHT, AE
中科院分区：
文献类型：
--
作者：
SENNETT, SH;POMPONI, SA;WRIGHT, AE
海洋海绵 Myrmekioderma styx 存在三种明显的化学型。一种无环二萜，styxenol A [1]，已从浅水化学型中分离出来，而三种三碳环二萜 3、6 和 7 已从深水化学型中分离出来。基于光谱方法（包括同核和异核二维核磁共振实验）阐明了结构。化合物 1、3 和 6 对 P-388 鼠白血病细胞系和 A549 人肺肿瘤细胞系表现出中等的细胞毒性。
Three apparent chemotypes of the marine sponge Myrmekioderma styx exist. An acyclic diterpene, styxenol A [1], has been isolated from the shallow water chemotype, while three tricarbocyclic diterpenes 3, 6, and 7 have been isolated from the deep chemotype. The structures were elucidated based on spectral methods including homo- and hetero-nuclear 2D nmr experiments. Compounds 1, 3, and 6 exhibit moderate cytotoxicity against the P-388 murine leukemia cell line and the A549 human lung tumor cell line.