Serum soluble interleukin-2 receptor as a predictor of lymph node metastasis in early gastric cancer
Serum soluble interleukin-2 receptor as a predictor of lymph node metastasis in early gastric cancer
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DOI：
10.1159/000051999
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发表时间：
2002-01-01
影响因子：
2.7
通讯作者：
Hirayama, R
中科院分区：
文献类型：
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作者：
Murakami, S;Sakata, H;Hirayama, R
背景资料：本研究旨在探讨血清可溶性IL-2R作为早期胃癌患者淋巴结转移预测指标的临床意义。患者和方法：74例早期胃癌患者入选本研究。血清可溶性IL-2R水平用酶联免疫吸附试验测定。结果.对照组和T1病例之间血清可溶性IL-2R无显著差异。74例早期胃癌患者血清可溶性IL-2R水平（T1）明显低于T2、T3、T4（p <0.05）。粘膜和粘膜下浸润病例的血清可溶性IL-2R无显著差异（379 +/-42 vs. 382 +/-35 U/ml）。35例黏膜下浸润者中6例（17.1%）有淋巴结转移，39例黏膜下浸润者无淋巴结转移。淋巴结转移6例，大体类型为IIc + Ul（+）4例，IIc + IIa和IIc + IIb各1例。组织学上，5例低分化腺癌和1例中分化腺癌。6例有淋巴结转移者血清可溶性IL-2R水平显著高于无淋巴结转移者（556.8 ± 73 vs.329 ± 22 U/ml，均数± SE M，p <0.05）。6例胃癌患者中5例血清可溶性IL-2R水平显著升高（敏感性83%，特异性63%），提示血清可溶性IL-2R可作为早期胃癌淋巴结转移的预测指标（p <0.05）。结论：根据这些数据，在血清可溶性IL-2R水平升高的早期胃癌患者中，应避免内镜粘膜切除术或未清除区域淋巴结的微创胃切除术，因为存在淋巴结转移的高风险。版权所有（C）2002 S. Karger AG，巴塞尔。
Background: In the present study, we investigated the clinical significance of serum soluble IL-2R as a predictor of lymph node metastasis in patients with early gastric cancer. Patients and Methods: Seventy-four patients with early gastric cancer were enrolled in this study. Levels of serum soluble IL-2R were measured by an enzyme-linked immunosorbent assay. Result. Significant differences in serum soluble IL-2R between the control group and cases of T1 were not recognized. On the other hand, levels of serum soluble IL-2R in 74 patients with early gastric cancer (T1) were significantly lower than those of T2, T3, and T4 (p < 0.05). There were no significant differences in serum soluble IL-2R between cases of mucosal and submucosal invasion (379 +/- 42 vs. 382 +/- 35 U/ml). Six of 35 patients with submucosal invasion (17.1%) had lymph node metastasis, but none of the 39 patients with mucosal invasion. In the 6 cases showing lymph node metastasis, the macroscopic types were Ilc + Ul(+) in 4, and IIc + Ila and IIc + IIb in 1, respectively. Histopathologically, there were 5 poorly and 1 moderately differentiated adenocarcinomas. In 6 cases with lymph node metastasis, serum soluble IL-2R levels were significantly higher than in those without lymph node metastasis (556.8 +/- 73 vs. 329 +/- 22 U/ml, respectively, mean +/- SE M, p < 0.05). Five of these 6 cases demonstrated statistically significantly increased levels of serum soluble IL-2R (sensitivity 83%, specificity 63%), suggesting serum soluble IL-2R as a predictor of lymph node metastasis in early gastric cancer (p < 0.05). Conclusion: According to these data, in patients of early gastric cancer with increased levels of serum soluble IL-2R, endoscopic mucosal resection or minimal invasive gastrectomy without dissection of regional lymph nodes should be avoided, since there is a high risk of lymph node metastasis. Copyright (C) 2002 S. Karger AG, Basel.