PET a tool for assessing the in vivo tumour cell and its microenvironment?
PET a tool for assessing the in vivo tumour cell and its microenvironment?
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DOI：
10.1093/bmb/lds041
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发表时间：
2013-03-01
影响因子：
6.7
通讯作者：
Wong, Bernadette
中科院分区：
文献类型：
--
作者：
Buscombe, John R.;Wong, Bernadette
正电子发射断层扫描（PET）已经开始超越其葡萄糖成像的根源，扩展到研究肿瘤及其微环境的其他参数。对过去5年成像文献的回顾表明，PET功能成像开始利用我们对基因组学和细胞表型表达以及它们如何相互作用的不断增加的知识与其微环境。对于大多数从事这项工作的人来说尽管PET提供了一种工具，通过它可以在体内评估肿瘤及其微环境，而不需要多次干预，PET的成本很高，并且重复研究会产生累积的辐射负担。随着PET扫描的数量和质量的提高，我们能够评估肿瘤细胞的转化、代谢、缺氧、血管生成以及可能影响肿瘤生存和治疗反应的各种其他因素。由于不可能为每个患者做所有事情，我们需要知道每个患者肿瘤细胞微环境中的关键因素，并需要有评估该因素的工具。
Positron emission tomography (PET) has started to develop beyond its roots in glucose imaging, expanding to study other parameters of the tumour and its microenvironment.A review of imaging literature over the past 5 years has shown that functional imaging with PET is starting to exploit our increasing knowledge of genomics and the phenotypic expression of cells and how they interact with their microenvironment.For most of those working in this field, there is agreement that therapeutic outcomes for patients can only be obtained by the assessment and continued reassessment not only of the tumour microenvironment, but also how it is changed by treatment.Although PET offers a tool by which the tumour and its microenvironment can be assessed in vivo without the need for multiple interventions, the cost of PET is high and there is a cumulative radiation burden with repeated studies. As the quantity and quality of PET scans increase, we are able to assess tumour cell turn over, metabolism, hypoxia, angiogenesis and a variety of other factors that might affect tumour survival and response to treatment.As it is impossible to do everything for every patient, we need to know what are the critical factors in the tumour cell microenvironment in each patient and need to have the tools to assess that factor.