Development of endometriosis from embryonic duct remnants
Development of endometriosis from embryonic duct remnants
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DOI：
10.1016/s0046-8177(98)90110-1
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发表时间：
1998-04-01
期刊：
影响因子：
3.3
通讯作者：
Parks, W
中科院分区：
文献类型：
--
作者：
Mai, KT;Yazdi, HM;Parks, W
在18例卵巢和输卵管子宫内膜异位症中，我们发现3例子宫内膜异位症病灶邻近输卵管胚胎导管残留物。包含感兴趣区域的组织块的连续切片显示胚胎导管残余片段，其变化表明逐渐转化为子宫内膜腺体。早期的变化包括替代周围的胚胎导管残留的子宫内膜间质与雌激素受体的免疫反应阳性上皮细胞的肌被。随后，胚胎导管残端上皮转变为子宫内膜上皮，具有弥漫性雌激素受体免疫反应。这种转变作为子宫内膜异位症发展机制的意义进行了讨论。版权所有（C）1998由W.B.桑德斯公司
Among 18 cases of endometriosis involving ovaries and fallopian tubes, we identified three cases with foci of endometriosis adjacent to the embryonic duct remnants in the fallopian tube. The serial sections of the blocks of tissue containing areas of interest showed segments of embryonic duct remnants with changes suggestive of gradual transformation to endometrial glands. The early changes consisted of replacement of the muscular coat surrounding the epithelium of embryonic duct remnants by the endometrial stroma with positive immunoreactivities for estrogen receptor. Subsequently there were changes of the embryonic duct remnant epithelium into endometrial epithelium with diffuse immunoreactivities for estrogen receptor. The significance of this transformation as a mechanism of develop ment of endometriosis is discussed. Copyright (C) 1998 by W.B. Saunders Company.