Renal effects of iodixanol in healthy volunteers and patients with severe renal failure
Renal effects of iodixanol in healthy volunteers and patients with severe renal failure
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DOI：
10.1177/0284185195036s39923
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发表时间：
1995-01-01
期刊：
影响因子：
1.3
通讯作者：
Jakobsen, JA
中科院分区：
文献类型：
--
作者：
Jakobsen, JA
造影剂（CM）诱发的肾病可能从急性肾功能衰竭到肾小管功能测试的微小变化等症状中表现出来。虽然发病率通常较低，但随着危险因素的存在和进行动脉注射，发病率会增加。发病机制尚不完全清楚。没有具体的治疗方法，但在大多数情况下，可以通过在注射 CM 之前确保患者水分充足来预防。碘克沙醇 (Visipaque) 的扩展 I 期研究包括对其肾脏影响的详细研究。未发现肾小球滤过率（GFR）发生变化。尽管注射碘克沙醇后的酶尿不如注射各种单体 CM 后明显，但注射碘克沙醇后，在肾脏 CT 检查中观察到 CM 肾内滞留程度稍高。在患有严重肾功能衰竭的非糖尿病患者中，使用碘克沙醇或碘海醇进行血管造影不会导致 GFR 或蛋白质和酶的尿排泄量发生变化。然而，发现对比剂保留程度高于健康志愿者。
Contrast medium- (CM) induced nephropathy may be evident from symptoms ranging from acute renal failure to minor changes in tubular function tests. While the incidence is usually low, it increases with the presence of risk factors and when arterial injections are made. The pathogenesis is not fully understood. No specific therapy exists, but in most cases it can be prevented by ensuring that the patient is well hydrated prior to injection of CM.The extended phase I study with iodixanol (Visipaque) included detailed investigations on its renal effects. No changes in glomerular filtration rate (GFR) were found. Even though enzymuria was less pronounced after injection of iodixanol than after various monomeric CM, a somewhat higher degree of intrarenal retention of CM was observed on CT examination of the kidneys after iodixanol. In nondiabetic patients suffering from severe renal failure, angiography with either iodixanol or iohexol caused no changes in GFR, or in urinary excretion of protein and enzymes. However, a higher degree of contrast retention than that seen in healthy volunteers was found.