DIVERSIFICATION OF THE WNT GENE FAMILY ON THE ANCESTRAL LINEAGE OF VERTEBRATES
DIVERSIFICATION OF THE WNT GENE FAMILY ON THE ANCESTRAL LINEAGE OF VERTEBRATES
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DOI：
10.1073/pnas.89.11.5098
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发表时间：
1992-06-01
影响因子：
11.1
通讯作者：
SIDOW, A
中科院分区：
文献类型：
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作者：
SIDOW, A
Wnt基因是一个强大的发育调节分子家族，通过分子进化分析推测其多样性。分析了55个最近确定的来自各种脊椎动物和无脊椎动物的部分序列，以及17个已发表的序列，主要来自老鼠和果蝇。WNT-1至WNT-7起源于节肢动物和后口动物的最后一个共同祖先生活之前。另一轮基因复制，涉及Wnt-3、-5、-7和-10，发生在棘皮动物谱系出现后，在有颌骨脊椎动物的祖先谱系上。当有颌骨脊椎动物起源时，对Wnt基因施加了更多的限制，这表明有颌骨脊椎动物的氨基酸替换率总体上比无脊椎动物和无颌骨脊椎动物低4倍。因此，Wnt基因在棘皮动物谱系起源和第一次颌骨脊椎动物多样化之间的相对较短的时间(几乎相当于1亿年)内经历了不成比例的高数量的结构和功能进化。建立了发育调节剂功能多样性与氨基酸替代率之间的关系模型。
Diversification of the Wnt genes, a family of powerful developmental regulator molecules, is inferred by molecular evolutionary analyses. Fifty-five recently determined partial sequences from a variety of vertebrates and invertebrates, together with 17 published sequences, mostly from the mouse and Drosophila melanogaster, are analyzed. Wnt-1 through -7 originated before the last common ancestor of arthropods and deuterostomes lived. Another round of gene duplication, involving Wnt-3, -5, -7, and -10, occurred after the echinoderm lineage arose, on the ancestral lineage of jawed vertebrates. Increased constraints were imposed on the Wnt genes when jawed vertebrates originated, as indicated by an overall 4-fold lower rate of amino acid replacements in jawed vertebrates compared with invertebrates and jawless vertebrates. The Wnt genes are thus inferred to have undergone a disproportionately high amount of structural and functional evolution in the relatively short time (almost-equal-to 100 million years) between the origin of the echinoderm lineage and the first diversification of jawed vertebrates. A model is presented for the relationship of functional diversification of developmental regulators and their rates of amino acid replacement.