Development of novel collagen scaffolds with different bioceramic particles for bone tissue engineering
Development of novel collagen scaffolds with different bioceramic particles for bone tissue engineering
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DOI：
10.1016/j.coco.2019.08.012
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发表时间：
2019-12-01
影响因子：
8
通讯作者：
Todo, Mitsugu
中科院分区：
文献类型：
--
作者：
Arahira, Takaaki;Todo, Mitsugu
包含天然聚合物和生物陶瓷颗粒的多孔支架最近已用于组织工程。胶原蛋白是一种提供有利生物条件的天然聚合物;例如，它刺激细胞作为细胞外基质的生成和分化。α-磷酸三钙（alpha-TCP）和β-磷酸三钙（beta-TCP）由于其良好的骨传导性、细胞粘附性、加速分化和机械性能也已广泛用于骨组织工程。在本研究中，通过改变α-TCP和β-TCP颗粒的比例，成功地制备了具有不同生物陶瓷颗粒的胶原支架。我们的研究结果表明，材料性能，如压缩模量，溶胀行为，和孔隙率，可以通过改变α-TCP和β-TCP颗粒的比例进行控制。
Porous scaffolds comprising natural polymers and bioceramic particles have recently been used in tissue engineering. Collagen is one such natural polymer providing favorable biological conditions; for example, it stimulates the generation and differentiation of cells as an extracellular matrix. alpha-Tricalcium phosphate (alpha-TCP) and beta-tricalcium phosphate (beta-TCP) have also been widely used in bone tissue engineering owing to their favorable osteoconductivity, cellular adhesion, accelerated differentiation, and mechanical properties. In the present study, collagen scaffolds with different bioceramic particles were successfully fabricated by varying the ratio of alpha-TCP and beta-TCP particles. Our results indicate that material properties, such as compressive modulus, swelling behavior, and porosity, can be controlled by varying the ratio of alpha-TCP and beta-TCP particles.