HLA antigens and complotypes in insulin-dependent diabetes mellitus.
HLA antigens and complotypes in insulin-dependent diabetes mellitus.
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胰岛素依赖性糖尿病中的 HLA 抗原和复合型。
DOI：
10.1111/j.1399-0039.1986.tb01535.x
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
M. Knip
中科院分区：
文献类型：
--
作者：
J. Partanen;S. Koskimies;J. Ilonen;M. Knip
本文对芬兰136例胰岛素依赖型糖尿病患者进行了HLA-A、B、D和DR抗原以及Bf和C4等位型的检测。与健康对照组相比，HLA-A9、B8、B15、Dw3、Dw4、DR3、DR4、C4A0、C4B3的频率均有统计学意义的升高。约79%的患者有HLA-DR4抗原，53%的患者有HLA-DR3抗原。在21%的患者中发现了罕见的C4等位基因C4B3，而在对照组中只有2%（相对风险为16.35）。病因学分数（EF）值表明，HLA D/DR等位基因是IDDM的最佳标记，观察到HLA- dr4在糖尿病中的EF高达0.70。HLA、Bf和C4表型的检测表明，至少有两种超型“B15 BfS C4A3B3 D(R)4”和“B8 BfS C4A0B1 D(R)3”是1型糖尿病易感性的标志，三分之一的患者具有这些超型中的任何一种。DR2和Dw2抗原的保护作用也得到证实：未发现HLA-Dw2阳性患者，仅发现1例HLA-DR2阳性患者。
One hundred and thirty-six Finnish patients with insulin-dependent (type I) diabetes mellitus were investigated for the HLA-A, B, D and DR antigens as well as the Bf and C4 allotypes. The statistically significant increase in the frequencies of HLA-A9, B8, B15, Dw3, Dw4, DR3, DR4, C4A0 and C4B3 was observed when compared with the healthy controls. About 79% of the patients had HLA-DR4, and 53% had HLA-DR3 antigens. A rare C4 allele C4B3 was found in 21% of the patients, whereas only in 2% among the controls (relative risk 16.35). The etiological fraction (EF) values indicated that HLA D/DR alleles were the best markers for IDDM, the observed EF for HLA-DR4 in diabetes was as high as 0.70. Examination of HLA, Bf and C4 phenotypes suggested that at least two supratypes "B15 BfS C4A3B3 D(R)4" and "B8 BfS C4A0B1 D(R)3" were markers for the susceptibility to type I diabetes, one third of our patients had either of these supratypes. The protective role of DR2 and Dw2 antigens was also confirmed: no HLA-Dw2 positive patients and only one with HLA-DR2 was found.