The Metabolomics of Asthma Novel Diagnostic Potential
The Metabolomics of Asthma Novel Diagnostic Potential
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DOI：
10.1378/chest.11-2028
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发表时间：
2012-05-01
期刊：
影响因子：
9.6
通讯作者：
Rowe, Brian H.
中科院分区：
文献类型：
--
作者：
Adamko, Darryl J.;Sykes, Brian D.;Rowe, Brian H.
哮喘是最常见的慢性疾病之一，尤其是儿童。哮喘的诊断和治疗比其他慢性病更困难。例如，哮喘是一种异质性综合征，具有基于患者症状、肺功能和对治疗的反应的许多临床分类。通常用于指导治疗的肺功能的症状和客观测量主要基于气道的炎症。因为在典型的临床环境中测量气道功能障碍和炎症是困难的，所以通常不这样做。代谢组学是研究由细胞代谢活动产生的小分子。患有慢性疾病（如哮喘）的患者的代谢谱可能与健康患者或患有其他呼吸系统疾病的患者不同。此外，如果可以测量这种代谢组，它也可能随着疾病的严重程度而变化。代谢物的模式成为代表疾病的诊断。本文概述了最近的工作，已经做了开发哮喘的代谢组学概况。胸部2012; 141（5）：1295-1302
Asthma is one of the most common chronic illnesses, especially in children. Reaching the diagnosis of asthma and its management are more difficult than for other chronic illnesses. For example, asthma is a heterogeneous syndrome with many clinical classifications based on patient symptoms, lung function, and response to therapy. The symptoms and objective measurements of lung function, often used to guide therapy, are largely based on the inflammation of the airways. Because measuring airway dysfunction and inflammation in a typical clinical setting is difficult, it is often not done. Metabolomics is the study of small molecules generated from cellular metabolic activity. It is possible that the metabolic profile of a patient with a chronic illness such as asthma is different from that of a healthy patient or from a patient with another respiratory illness. Furthermore, if this metabolome could be measured, it might also vary with disease severity. The pattern of metabolites becomes the diagnostic representing the disease. This article outlines the more recent work that has been done to develop the metabolomic profile of asthma. CHEST 2012; 141(5):1295-1302