Case report of a patient with chemotherapy-induced peripheral neuropathy treated with manual therapy (massage)
Case report of a patient with chemotherapy-induced peripheral neuropathy treated with manual therapy (massage)
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DOI：
10.1007/s00520-011-1231-8
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发表时间：
2011-09-01
影响因子：
3.1
通讯作者：
Chin, Steve H.
中科院分区：
文献类型：
--
作者：
Cunningham, Joan Elizabeth;Kelechi, Teresa;Chin, Steve H.
化疗引起的周围神经病变（CIPN）是一种常见的、痛苦的、潜在的严重副作用，通常是一些一线和二线抗癌药物的剂量限制副作用，几乎没有有效的、可接受的治疗方法。尽管损伤机制不同，但手工治疗（治疗性按摩）有效地减轻了糖尿病周围神经病变患者的症状并改善了生活质量。方法在此，我们描述了在多西他赛和顺铂治疗III期食管腺癌后，对2级CIPN患者的四肢进行手工治疗（排液和结石技术）的应用。用红外测温仪监测浅表皮肤温度，作为微血管血流的代用物。结果在不改变药物的情况下，手工治疗结束时，CIPN症状明显减轻至1级，生活质量相应改善。观察到手指和脚趾的表面温度有所改善。结论手工治疗与该患者CIPN的刺痛、麻木和疼痛几乎完全消除有关。同时，体表温度升高提示CIPN症状的改善可能涉及血液循环的改变。据我们所知，这是第一份使用手工疗法改善CIPN的报告。
Purpose Chemotherapy-induced peripheral neuropathy (CIPN) is a common, miserable, potentially severe, and often dose-limiting side effect of several first and second-line anti-cancer agents with little in the way of effective, acceptable treatment. Although mechanisms of damage differ, manual therapy (therapeutic massage) has effectively reduced symptoms and improved quality of life in patients with diabetic peripheral neuropathy.Methods Here, we describe application of manual therapy (techniques of effleurage and petrissage) to the extremities in a patient with grade 2 CIPN subsequent to prior treatment with docetaxel and cisplatin for stage III esophageal adenocarcinoma. Superficial cutaneous temperature was monitored using infrared thermistry as proxy for microvascular blood flow.Results By the end of the course of manual therapy without any change in medications, CIPN symptoms were greatly reduced to grade 1, with corresponding improvement in quality of life. Improvements in superficial temperature were observed in fingers and toes.Conclusions Manual therapy was associated with almost complete resolution of the tingling and numbness and pain of CIPN in this patient. Concurrently increased superficial temperature suggests improvements in CIPN symptoms may have involved changes in blood circulation. To our knowledge, this is the first report of using manual therapy for amelioration of CIPN.