Atopic asthma and TNF-308 alleles: Linkage disequilibrium and association analyses
Atopic asthma and TNF-308 alleles: Linkage disequilibrium and association analyses
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DOI：
10.1016/s0198-8859(02)00819-4
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发表时间：
2003-03-01
期刊：
影响因子：
2.7
通讯作者：
Ruffilli, A
中科院分区：
文献类型：
--
作者：
Di Somma, C;Charron, D;Ruffilli, A
肿瘤坏死因子-308等位基因（TNF 2）与哮喘的相关性在一些研究中有报道，但在其他研究中没有报道。本研究的目的是在对Parietaria过敏的基础上招募的人群中测试这种关联。在研究人群中，哮喘与HLA-DRB 1 *03（p = 0.01）和单倍型TNF 2/DRB 1 *03（p = 0.02）呈正相关。在父母亚组中，TNF 2患者的哮喘比例增加（p = 0.01），但哮喘的主要相关性是单倍型TNF 2/DRB 1 *1104（p = 0.005）。研究人群根据点刺皮肤试验（ST）对黑麦草属、墙草属和D. pteronyssinus。哮喘与HLA-DRB 1 *03和单倍型TNF 2/DRB 1 *03（分别为p = 0.0015和0.0001）相关，与单倍型TNF 2/DRB 1 *1104（p = 0.025）相关。传递不平衡检验检测到HLA-DRB 1 *03和单倍型TNF 2/DRB 1 *03的过度传递（p值分别为0.03和0.04）与哮喘和ST对Lolium和HLA-DRB 1 *1104和单倍型TNF 2/DRB 1 *1104阳性的同胞（分别为p = 0.04和0.015）与哮喘和ST阳性的兄弟姐妹Parietaria。总之，这些观察结果表明，单倍型TNF 2/DRB 1 *03和TNF 2/*B1*1104含有等位基因控制过敏性哮喘患者与致敏黑麦草和Parietaria，分别。这表明哮喘与TNF 2的关联反映了与影响特异性免疫应答的基因的连锁不平衡。
The association of a tumor necrosis factor -308 allele (TNF2) to asthma has been reported in some studies but not in others. The aim of this study was to test this association in a population recruited on the basis of allergy to Parietaria. In the study population, asthma was positively associated to HLA-DRB1*03 (p = 0.01) and to the haplotype TNF2/DRB1*03 (p = 0.02). In the parent subgroup, the proportion of asthmatics was increased in patients with TNF2 (p = 0.01), but the primary association of asthma was to the haplotype TNF2/DRB1*1104 (p = 0.005). The study population was subdivided according to prick skin test (ST) positivity to Lolium, Parietaria, and D. pteronyssinus. Asthma was associated to HLA-DRB1*03 and to the haplotype TNF2/DRB1*03 (p = 0.0015 and 0.0001, respectively) in patients ST positive to Lolium, and to the haplotype TNF2/DRB1*1104 (p = 0.025) in patients ST positive to Parietaria. The transmission disequilibrium test detected excess transmission of HLA-DRB1*03 and of the haplotype TNF2/DRB1*03 (p = 0.03 and 0.04, respectively) to siblings with asthma and ST positivity to Lolium and of HLA-DRB1*1104 and of the haplotype TNF2/DRB1*1104 (p = 0.04 and 0.015, respectively) to siblings with asthma and ST positivity to Parietaria. Taken together, these observations indicate that the haplotypes TNF2/DRB1*03 and TNF2/*B1*1104 contain alleles controlling atopic asthma in patients with sensitization to Lolium and Parietaria, respectively. This suggests that the association of asthma to TNF2 reflects linkage disequilibrium with genes influencing specific immune response.