RADIOLYSIS OF DNA IN AQUEOUS-SOLUTION IN THE PRESENCE OF A SCAVENGER - A KINETIC-MODEL BASED ON A NONHOMOGENEOUS REACTION OF OH RADICALS WITH DNA-MOLECULES OF SPHERICAL OR CYLINDRICAL SHAPE
RADIOLYSIS OF DNA IN AQUEOUS-SOLUTION IN THE PRESENCE OF A SCAVENGER - A KINETIC-MODEL BASED ON A NONHOMOGENEOUS REACTION OF OH RADICALS WITH DNA-MOLECULES OF SPHERICAL OR CYLINDRICAL SHAPE
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DOI：
10.1007/bf01210293
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发表时间：
1989-01-01
影响因子：
1.7
通讯作者：
SCHULTEFROHLINDE, D
中科院分区：
文献类型：
--
作者：
MARK, F;BECKER, U;SCHULTEFROHLINDE, D
对于在存在清除剂的情况下在水溶液中暴露于高能辐射的 DNA 的存活剂量，给出了两种表达方式。它们源自一个模型，其中 OH 自由基的扩散控制反应发生在 DNA 大分子表面，与溶液主体中的清除竞争。 DNA 分子近似为球体或圆柱体。基于球形分子的模型与 van Rijn 等人开发的模型密切对应。 [20]。从圆柱模型获得的表达式用于解释一些实验测量量对清除剂浓度的依赖性，即分别是.PHI.X174 DNA和聚腺苷酸在Coγ-辐射下的单链断裂的存活剂量和G值。
Two expressions are given for the survival dose of DNA exposed to high-energy radiation in aqueous solution in the presence of a scavenger. They are derived from a model where a diffusion controlled reaction of OH radicals occurs on the surface of the DNA macromolecules in competition with scavenging in the bulk of the solution. The DNA molecules are approximated either by spheres or by cylinders. The model based on molecules of spherical shape corresponds closely to that developed by van Rijn et al. [20]. Expressions obtained from the cylindrical model are used to account for the dependence on the scavenger concentration of some experimentally measured quantities, namely the survival dose and the G value for single-strand breaks upon Co .gamma.-irradiation of .PHI.X174 DNA and polyadenylic acid, respectively.