Vitamin B6 supplementation increases immune responses in critically ill patients
Vitamin B6 supplementation increases immune responses in critically ill patients
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DOI：
10.1038/sj.ejcn.1602439
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发表时间：
2006-10-01
影响因子：
4.7
通讯作者：
Huang, Y-C
中科院分区：
文献类型：
--
作者：
Cheng, C-H;Chang, S-J;Huang, Y-C
目的：探讨补充维生素B-6对危重患者免疫反应的有益影响。设计：单盲干预研究。背景：本研究在台湾中部的台中退伍军人总医院进行。受试者：51名在重症监护室待了14天以上的受试者完成了研究。受试者在干预前未服用任何维生素补充剂。干预措施：患者被随机分为三组，对照组（n = 20），每天注射50毫克维生素B-6 (B-6-50, n = 15)，或100毫克维生素B-6 (B-6-100, n = 16)，持续14天。主要观察指标：测定血浆吡哆醛5′-磷酸（PLP）、吡哆醛（PL）、4-吡哆酸（4-PA）、红细胞丙氨酸（EALT-AC）、天冬氨酸（EAST-AC）转氨酶活性系数、尿液4-PA。测定血清白蛋白、血红蛋白、红细胞压积、高敏c反应蛋白（hs-CRP）水平和免疫应答(白细胞、中性粒细胞、淋巴细胞总计数（TLC）、T-(CD3)和B-（CD19)淋巴细胞、T辅助细胞（CD4）和抑制细胞（CD8））水平。结果：两组患者血浆PLP、PL、4-PA及尿4-PA浓度均显著升高。第14天，B-6-50组t淋巴细胞和t辅助细胞数量及t抑制细胞百分比显著升高。第14天，B-6-100组淋巴细胞总数、t辅助细胞和t抑制细胞数量、t淋巴细胞和t抑制细胞百分比均显著升高。在14天的时间里，对照组的免疫反应没有明显变化。结论：大剂量补充维生素B-6（50或100 mg/ d）可弥补血浆PLP对维生素B-6摄入的反应性不足，进一步提高危重患者的免疫反应。
Objective: To investigate whether vitamin B-6 supplementation has a beneficial effect on immune responses in critically ill patients.Design: A single-blind intervention study.Setting: The study was performed at the Taichung Veterans General Hospital, the central part of Taiwan.Subjects: Fifty-one subjects who stayed over 14 days in the intensive care unit completed the study. Subjects were not treated with any vitamin supplement before the intervention. Interventions: Patients were randomly assigned to one of three groups, control (n = 20), a daily injection of 50 mg vitamin B-6 (B-6-50, n = 15), or 100 mg vitamin B-6 (B-6-100, n = 16) for 14 days.Main outcome measures: Plasma pyridoxal 5'-phosphate (PLP), pyridoxal (PL), 4-pyridoxic acid (4-PA), erythrocyte alanine (EALT-AC) and aspartate (EAST-AC) aminotransaminase activity coefficient, and urinary 4-PA were measured. The levels of serum albumin, hemoglobin, hematocrit, high-sensitivity C-reactive protein (hs-CRP) and immune responses (white blood cell, neutrophils, total lymphocytes count (TLC), T-(CD3) and B-(CD19) lymphocytes, T-helper (CD4) and suppressor (CD8) cells) were determined.Results: Plasma PLP, PL, 4-PA and urinary 4-PA concentrations significantly increased in two treated groups. T-lymphocyte and T-helper cell numbers and the percentage of T-suppressor cell significantly increased on day 14 in the B-6-50 group. Total lymphocyte count, T-helper and T-suppressor cell numbers, the percentage of T-lymphocyte cells and T-suppressors significantly increased in the B-6-100 group at the 14th day. There were no significant changes with respect to immune responses in the control group over 14 days.Conclusions: A large dose of vitamin B-6 supplementation (50 or 100 mg/ day) could compensate for the lack of responsiveness of plasma PLP to vitamin B-6 intake, and further increase immune response of critically ill patients. Sponsorship: This study was supported by the National Science Council, Taiwan, Republic of China (NSC-92-2320-B-040-026).